INT194705

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.46
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MAPK1, IK) nucleoplasm (MAPK1) mitochondrion (MAPK1)
DNA binding (MAPK1) microtubule organizing center (MAPK1) extracellular space (IK)
Anatomy Link Frequency
blood 3
MAPK1 (Homo sapiens)
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 100.00 Very High Very High Very High
headache 1 92.40 High High
Arthritis 3 84.52 Quite High
Inflammation 30 80.04 Quite High
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 3 95.40 Very High Very High Very High
Heart Rate Under Development 2 94.76 High High
Pressure Volume 2 Under Development 1 93.88 High High
Fever 1 92.84 High High
Headache 1 92.40 High High
Autoimmune Disease 14 90.72 High High
Arthritis 3 84.52 Quite High
INFLAMMATION 31 80.04 Quite High
Disease 10 76.36 Quite High
Acute Coronary Syndrome 2 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two different p38 MAPK inhibitors, BIRB-796 and RWJ-67657, have demonstrated clinical efficacy in a human endotoxin challenge model in which the inhibition of p38 MAPK was shown to decrease LPS-induced cytokine and C-reactive protein (CRP) production in vivo and to reduce LPS-induced clinical symptoms, for example those of sepsis (such as increased heart rate, decreased blood pressure, fever, and headache) [111,112].
Negative_regulation (inhibition) of p38 MAPK in blood Negative_regulation (decrease) of Positive_regulation (induced) of cytokine in blood associated with heart rate under development, pressure volume 2 under development, headache, fever, sepsis and cytokine
1) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 1.46 Pain Relevance 0.41

General Comments

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