INT19472

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 2011
Negated 16
Speculated 11
Reported most in Abstract
Documents 554
Total Number 570
Disease Relevance 419.75
Pain Relevance 175.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 41
monocytes 17
microglia 12
joints 11
neutrophils 9
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14185 100.00 Very High Very High Very High
cytokine 11900 100.00 Very High Very High Very High
chemokine 1992 100.00 Very High Very High Very High
antagonist 1058 100.00 Very High Very High Very High
Inflammatory mediators 942 100.00 Very High Very High Very High
agonist 743 100.00 Very High Very High Very High
psoriasis 161 100.00 Very High Very High Very High
Inflammatory stimuli 141 100.00 Very High Very High Very High
Morphine 191 99.98 Very High Very High Very High
anakinra 157 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 16249 100.00 Very High Very High Very High
Disease 7228 100.00 Very High Very High Very High
Injury 3262 100.00 Very High Very High Very High
Infection 2820 100.00 Very High Very High Very High
Targeted Disruption 2269 100.00 Very High Very High Very High
Cancer 1310 100.00 Very High Very High Very High
Keratitis 922 100.00 Very High Very High Very High
Necrosis 870 100.00 Very High Very High Very High
Sepsis 739 100.00 Very High Very High Very High
Hypoxia 386 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that IL-1 produces a marked anti-analgesic effect, suggests that it may also be involved in the development of opiate tolerance.
Gene_expression (produces) of IL-1 associated with analgesic, tolerance and opiate
1) Confidence 0.76 Published 2005 Journal Pain Section Abstract Doc Link 15836969 Disease Relevance 0.39 Pain Relevance 2.16
IL-1 production in response to LPS stimulation was similar in all groups.
Gene_expression (production) of IL-1
2) Confidence 0.76 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.64 Pain Relevance 0.37
Blood monocytes and synovial fluid and tissue macrophages were examined for their ability to produce interleukin-1 (IL-1) measured in a mouse thymocyte proliferation assay.
Gene_expression (produce) of IL-1 in Blood
3) Confidence 0.76 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.57 Pain Relevance 0.33
Synovial tissue macrophages produced little IL-1.
Neg (little) Gene_expression (produced) of IL-1 in macrophages
4) Confidence 0.76 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.60 Pain Relevance 0.34
Spontaneous production of IL-1 by monocytes from patients with rheumatoid arthritis (RA) or ankylosing spondylitis was higher than that by cells from normal subjects, patients with osteoarthritis or patients with RA treated with gold.
Gene_expression (production) of IL-1 in monocytes associated with spinal inflammation, rheumatoid arthritis and osteoarthritis
5) Confidence 0.76 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.63 Pain Relevance 0.36
Spontaneous IL-1 production by synovial fluid macrophages from patients with RA was similar to that of their monocytes, but the response to LPS was smaller.
Gene_expression (production) of IL-1 in macrophages associated with rheumatoid arthritis
6) Confidence 0.76 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.64 Pain Relevance 0.36
However, an upregulated lung expression for TNF-alpha and IL-1 receptors was observed in C57Bl/6J-sensitive animals only.
Gene_expression (expression) of IL-1 in lung
7) Confidence 0.75 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.47 Pain Relevance 0.43
The levels of TNF and IL-1?
Gene_expression (levels) of IL-1
8) Confidence 0.75 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.14 Pain Relevance 0.10
Thus, in this system, PGE2 has no effect on IL-1 synthesis, but rather has a direct inhibitory effect on thymocyte proliferation.
Gene_expression (synthesis) of IL-1 in thymocyte
9) Confidence 0.73 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0.09 Pain Relevance 0.09
IL-1 production was initially studied in the presence of piroxicam and indomethacin, both inhibitors of prostaglandin biosynthesis.
Gene_expression (production) of IL-1
10) Confidence 0.73 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
Further dilutions of the drug-treated supernatants gave thymocyte proliferation responses which were indistinguishable from control cultures and, correspondingly, had identical values for IL-1 production.
Gene_expression (production) of IL-1 in thymocyte
11) Confidence 0.73 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
The role of prostaglandins in the regulation of lipopolysaccharide (LPS)-induced interleukin-1 (IL-1) production by murine C3H/HeN resident peritoneal macrophages was studied.
Gene_expression (production) of IL-1 in peritoneal macrophages
12) Confidence 0.73 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs are not stimulating IL-1 production but are, in fact, relieving inhibition of the thymocyte IL-1 assay caused by the presence of prostaglandins.
Gene_expression (production) of IL-1 in thymocyte associated with inflammation and cinod
13) Confidence 0.73 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0.10 Pain Relevance 0.10
In the present study, we tested the role of IL-1 in neuropathic pain models using two mouse strains impaired in IL-1 signaling: Deletion of the IL-1 receptor type I (IL-1rKO) and transgenic over-expression of the IL-1 receptor antagonist (IL-1raTG).
Gene_expression (over-expression) of IL-1 associated with targeted disruption, antagonist, eae and sprains and strains
14) Confidence 0.70 Published 2006 Journal Pain Section Abstract Doc Link 16426759 Disease Relevance 1.55 Pain Relevance 0.86
The role of the neuropeptide beta-endorphin on interleukin 1 (IL-1) production by murine bone marrow-derived macrophages was assessed.
Gene_expression (production) of IL-1 in macrophages associated with neuropeptide
15) Confidence 0.68 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.12
Naloxone, a competitive inhibitor of beta-endorphin opioid receptor interactions, abrogated the enhancing effects of beta-endorphin on LPS-induced IL-1 production.
Gene_expression (production) of IL-1 associated with narcan and opioid receptor
16) Confidence 0.68 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.30
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Gene_expression (production) of IL-1 in macrophages associated with narcan and opioid
17) Confidence 0.68 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.31
However, over a wide range of concentrations (10(-6)-10(-14) M) beta-endorphin potentiated lipopolysaccharide (LPS)- or silica-induced production of intracellular and extracellular IL-1.
Gene_expression (production) of IL-1
18) Confidence 0.68 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.26
METHODS: The clearance of charcoal particles, the immune organ weights, the white blood cell counts in peripheral blood, the phagocytosis to neutral red (NR) of PMO and its IL-1 production in vitro were tested.
Gene_expression (production) of IL-1 in blood
19) Confidence 0.68 Published 1997 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10322945 Disease Relevance 0 Pain Relevance 0
RESULTS: In normal mice, Bru slightly enhanced the clearance of charcoal particles, the phagocytosis of PMO, IL-1 production, the immune organ weights and the WBC counts (P > 0.05), whereas in Cyc-induced subnormal immunity model mice, Bru greatly enhanced these nonspecific immune responses (P < 0.05 or P < 0.01).
Gene_expression (production) of IL-1
20) Confidence 0.68 Published 1997 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10322945 Disease Relevance 0 Pain Relevance 0

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