INT194730

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) DNA binding (MAPK1)
microtubule organizing center (MAPK1) extracellular space (IL2) nucleus (MAPK1)
Anatomy Link Frequency
T cells 6
MAPK1 (Homo sapiens)
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 94.16 High High
Inflammation 60 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 5.00 Very Low Very Low Very Low
Autoimmune Disease 28 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Asthma 6 5.00 Very Low Very Low Very Low
Sepsis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the p38 MAPK signaling cascade downregulates IL-2 promoter activity and IL-2 production in Jurkat T cells [62].
Negative_regulation (Inhibition) of p38 MAPK in T cells Negative_regulation (downregulates) of Gene_expression (production) of IL-2 in T cells
1) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.05
Inhibition of the p38 MAPK signaling cascade downregulates IL-2 promoter activity and IL-2 production in Jurkat T cells [62].
Negative_regulation (Inhibition) of p38 MAPK in T cells Negative_regulation (downregulates) of Gene_expression (production) of IL-2 in T cells
2) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.05

General Comments

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