INT194731

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.04

response to stress (MAP3K4, MAPK8) cytoplasm (MAP3K4, MAPK8) cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8) nucleus (MAPK8)

MAP3K4 (Homo sapiens) MAPK8 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 34 83.36 Inflammation 30 5.00 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Stress 6 6.32 INFLAMMATION 31 5.00 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00 Necrosis 3 5.00 Asthma 3 5.00 Sepsis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GADD45 proteins can bind the autoinhibitory domain of MEKK4 (MKKK), which is an upstream activator of p38 MAPK and JNK, and relieve the autoinhibition of MEKK4, leading to activation of the MAPK cascade [27].

MEKK4 Positive_regulation (activator) of JNK

1) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.04

General Comments

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