INT194733

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HNRNPA0) mitochondrion (CPOX) small molecule metabolic process (CPOX)
cytoplasm (CPOX) oxidoreductase activity (CPOX) mRNA processing (HNRNPA0)
CPOX (Homo sapiens)
HNRNPA0 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 93.52 High High
Inflammation 60 66.52 Quite High
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 2 78.64 Quite High
Hypersensitivity Pneumonitis 2 73.52 Quite High
INFLAMMATION 62 66.52 Quite High
Disease 20 34.88 Quite Low
Autoimmune Disease 28 24.00 Low Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An additional mechanism by which MK2 may regulate mRNA stability may be through the phosphorylation of the heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0), which then binds to the AREs of TNF, COX-2, and MIP-2 mRNA and stabilizes these mRNAs [91].
COX Binding (binds) of hnRNP A0
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.22 Pain Relevance 0.16
An additional mechanism by which MK2 may regulate mRNA stability may be through the phosphorylation of the heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0), which then binds to the AREs of TNF, COX-2, and MIP-2 mRNA and stabilizes these mRNAs [91].
COX Binding (binds) of nuclear ribonucleoprotein A0
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.22 Pain Relevance 0.16

General Comments

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