INT19475

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 17.99
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
plaques 2
lung 2
Plasma 1
Granulocyte 1
macrophage 1
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 166 100.00 Very High Very High Very High
cytokine 150 100.00 Very High Very High Very High
chemokine 26 100.00 Very High Very High Very High
narcan 3 99.40 Very High Very High Very High
Hyperalgesia 1 99.24 Very High Very High Very High
Endogenous opioid 4 99.06 Very High Very High Very High
Arthritis 107 98.64 Very High Very High Very High
Migraine 8 98.32 Very High Very High Very High
Thermal hyperalgesia 2 98.24 Very High Very High Very High
headache 20 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 201 100.00 Very High Very High Very High
Fever 20 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 11 99.94 Very High Very High Very High
Toxicity 45 99.88 Very High Very High Very High
Amyloid Plaque 2 99.84 Very High Very High Very High
Cancer 41 99.52 Very High Very High Very High
Necrosis 14 99.28 Very High Very High Very High
Hyperalgesia 3 99.24 Very High Very High Very High
Rheumatoid Arthritis 111 98.64 Very High Very High Very High
Disease 178 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies suggest increased levels of pro-inflammatory cytokines, such as IL-1alpha, sTNF-RI and TNF-alpha, in children with migraine headaches.
Positive_regulation (increased) of IL-1alpha associated with inflammation, migraine, headache and cytokine
1) Confidence 0.67 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20508283 Disease Relevance 0.94 Pain Relevance 1.32
IL1A:rs1800587 has been shown to contribute to an increase in IL1-?
Positive_regulation (increase) of IL1
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.74 Pain Relevance 0.18
Increased serum levels of IL-1alpha was noticed in all patients, high levels of IL-6, IFN-gamma and GM-CSF were observed only in a patient with severe envenomation.
Positive_regulation (Increased) of IL-1alpha
3) Confidence 0.67 Published 1999 Journal Toxicon Section Abstract Doc Link 10400299 Disease Relevance 1.06 Pain Relevance 0.27
Additionally cytokines, such as interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are co-localized to senile plaques, a neuropathological hallmark of AD.
Positive_regulation (co-localized) of interleukin-1alpha in plaques associated with disease, amyloid plaque and cytokine
4) Confidence 0.49 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.79 Pain Relevance 0.52
Additionally cytokines, such as interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are co-localized to senile plaques, a neuropathological hallmark of AD.
Positive_regulation (co-localized) of IL-1alpha in plaques associated with disease, amyloid plaque and cytokine
5) Confidence 0.49 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.78 Pain Relevance 0.52
8 mM accumulation in lysosomes (Fig. 2i–l), fifty-six (56) lie below the accumulation threshold (Fig. 2i, j) while forty-three (43) are above the threshold (Fig. 2k, l).
Positive_regulation (accumulation) of i-l
6) Confidence 0.49 Published 2008 Journal J Comput Aided Mol Des Section Body Doc Link PMC2516532 Disease Relevance 0 Pain Relevance 0
There were no differences in chemotherapy-induced hematologic toxicity with increasing doses of rhuIL-1 alpha or in comparisons before or after ICE chemotherapy.
Positive_regulation (increasing) of rhuIL-1 alpha associated with toxicity
7) Confidence 0.47 Published 1997 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 9143391 Disease Relevance 0.87 Pain Relevance 0.09
precursor resulting in an increase in the levels of active IL1-?
Positive_regulation (increase) of IL1
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.79 Pain Relevance 0.19
The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone.
Positive_regulation (up-regulated) of IL-1alpha
9) Confidence 0.45 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.25
Paradoxically, constant inflammatory signals provided by the significant increase in several chemokines (CCL2, CCL3, CCL19, CXCL8, CXCL10, CXCL11) and pro-inflammatory cytokines (IL6, IL17, IL1A, IL1B, TNF) in the lung cells may have resulted in massive infiltration of leucocytes and excessive tissue damage.
Positive_regulation (increase) of IL1A in lung associated with chemokine, inflammation and cytokine
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.66 Pain Relevance 0.29
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of IL1A in lung associated with chemokine and cytokine
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotential hematopoietin.
Positive_regulation (multipotential) of hematopoietin in Granulocyte
12) Confidence 0.17 Published 1988 Journal Blood Section Abstract Doc Link 3291976 Disease Relevance 0.34 Pain Relevance 0
Patients with RA present constitutively high serum levels of pre-inflammatory cytokines, including TNF-, IL1 and IL6, which are NF-B target genes, suggesting activation of this pathway in the course of RA disease.
Positive_regulation (activation) of IL1 associated with inflammation, disease, cytokine and arthritis
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.05 Pain Relevance 0.45
Real time quantitative PCR was done to compare the induction of IL-1 alpha or beta-defensin 2 mRNAs and to identify the signaling pathways involved.
Positive_regulation (induction) of IL-1 alpha
14) Confidence 0.09 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.76 Pain Relevance 0.21
However, during a 3 week period without oral hygiene, both groups developed increased levels of IL-1a, whereas IL-1?
Positive_regulation (increased) of IL-1a
15) Confidence 0.03 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.96 Pain Relevance 0.30
is produced mainly by activated macrophages and T lymphocytes, among other cells, induces other proinflammatory cytokines including interleukin-1 (IL-1) and IL-6 and enhances leukocyte migration by inducing expression of adhesion molecules by endothelial cells and leukocytes.
Positive_regulation (induces) of interleukin-1 in endothelial cells associated with adhesions and cytokine
16) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936311 Disease Relevance 1.20 Pain Relevance 0.47
Plasma concentrations of IL-1 alpha, IL-1 beta, or IL-10 were not increased during attacks.
Neg (not) Positive_regulation (increased) of IL-1 alpha in Plasma
17) Confidence 0.02 Published 1995 Journal Blood Section Abstract Doc Link 7780142 Disease Relevance 1.11 Pain Relevance 0.25
HIV-1 induction of such cytokines as interleukin 1 (IL 1) and tumor necrosis factor-alpha (TNF alpha) may lead to an autocrine feedback loop involving further productive virus replication and induction of other cytokines such as interleukin 6 (IL 6) and granulocyte-macrophage colony-stimulating factor (GMCSF).
Positive_regulation (induction) of interleukin 1 in macrophage associated with necrosis, cancer, acquired immune deficiency syndrome or hiv infection and cytokine
18) Confidence 0.01 Published 1991 Journal FASEB J. Section Abstract Doc Link 2065887 Disease Relevance 2.53 Pain Relevance 0.45
is produced mainly by activated macrophages and T lymphocytes, among other cells, induces other proinflammatory cytokines including interleukin-1 (IL-1) and IL-6 and enhances leukocyte migration by inducing expression of adhesion molecules by endothelial cells and leukocytes.
Positive_regulation (induces) of interleukin-1 in leukocytes associated with adhesions and cytokine
19) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936311 Disease Relevance 1.20 Pain Relevance 0.47
Endogenous opioids (EO) probably do not modulate endotoxin (LPS)- or interleukin 1 (IL1)-induced fever because naloxone does not prevent its development.
Neg (not) Positive_regulation (-induced) of interleukin 1 associated with narcan, endogenous opioid and fever
20) Confidence 0.01 Published 1985 Journal Brain Res. Bull. Section Abstract Doc Link 2417670 Disease Relevance 0.19 Pain Relevance 0.64

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