INT194794

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.56
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TTPA) transport (TTPA) intracellular (TTPA)
lipid metabolic process (TTPA) cytoplasm (TTPA)
TTPA (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 385 98.88 Very High Very High Very High
Inflammation 60 87.76 High High
cytokine 73 80.32 Quite High
cva 29 51.12 Quite High
palliative 10 30.64 Quite Low
peripheral neuropathy 10 17.04 Low Low
aspirin 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 92 100.00 Very High Very High Very High
Vitamin Deficiency 1 100.00 Very High Very High Very High
Neurodegenerative Disease 1 98.42 Very High Very High Very High
Recurrence 10 98.28 Very High Very High Very High
Hypolipidemia 9 97.40 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 20 97.16 Very High Very High Very High
Endometriosis (extended) 8 95.36 Very High Very High Very High
Multiple Myeloma 176 89.24 High High
INFLAMMATION 63 87.76 High High
Cerebellar Ataxia 48 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the available agents, only letrozole has demonstrated significant improvements in ORR, TTP, and early OS.



TTP Binding (improvements) of
1) Confidence 0.08 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001219 Disease Relevance 0.26 Pain Relevance 0
However, no association was observed for the other polymorphisms and TTP or OS (Table 6).
TTP Binding (association) of
2) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0 Pain Relevance 0
Variables showing association with TTP in univariate analysis with p < 0.10 (6-bp deletion in TS-3'UTR, XPD- Arg156Arg, XPD-Asp312Asn, performance status) were included for multivariate analysis using Cox proportional hazard regression models.
TTP Binding (association) of
3) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.05 Pain Relevance 0
Binding of TTP to AREs in the 3' untranslated region leads to the rapid degradation of target mRNA.
TTP Binding (Binding) of
4) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.15
However, it should be noted that the interaction of 14-3-3 proteins with TTP and its role in mRNA stabilization has been recently questioned [99].
TTP Binding (interaction) of
5) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.18 Pain Relevance 0.14
Abetalipoproteinemia, which is associated with severe neurodegenerative complications, belongs to the potentially treatable or preventable conditions associated with vitamin E deficiency, similarly to ataxia with vitamin deficiency (AVED) due to mutations in the ?
AVED Binding (associated) of associated with ataxia, hypolipidemia, vitamin deficiency and neurodegenerative disease
6) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.54 Pain Relevance 0
Similarly, bortezomib monotherapy yielded a higher ORR than single-agent dexamethasone in the relapse setting (38% vs 18%, respectively) and a higher CR rate (6% vs 1%).56 Bortezomib was associated with improved TTP compared with single-agent dexamethasone (6.2 months vs 3.5 months, respectively) and one-year survival (80% vs 66%).
TTP Binding (associated) of associated with dexamethasone and recurrence
7) Confidence 0.00 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.43 Pain Relevance 0.29

General Comments

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