INT194801

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.90
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 37 99.72 Very High Very High Very High
Inflammation 67 97.68 Very High Very High Very High
cytokine 38 53.36 Quite High
rheumatoid arthritis 4 5.08 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Mechanotransduction 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 39 99.72 Very High Very High Very High
INFLAMMATION 71 97.68 Very High Very High Very High
Targeted Disruption 27 97.68 Very High Very High Very High
Renal Cancer 3 95.72 Very High Very High Very High
Hemangiosarcoma 139 94.80 High High
Cancer 113 90.24 High High
Amyloid Plaque 35 87.04 High High
Hematoma 22 82.28 Quite High
Adhesions 78 50.00 Quite Low
Prostate Cancer 54 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myometrial SmAV associates with tyrosine-phosphorylated proteins and ERK in a stretch-dependent manner
ERK Binding (associates) of
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
However, and in contrast to ATP, these compounds can bind to both the active and inactive (unphosphorylated) forms of p38, providing an advantage over ATP and resulting in a very potent inhibitory capacity, regardless of high intracellular ATP concentrations [17].
p38 Binding (bind) of
2) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.03
HNE-binding to Col II activates p38 MAPK, ERK1/2 and NF-?
p38 MAPK Binding (binding) of
3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.32 Pain Relevance 0.16
FIGURE 6.JNK, but not ERK or PKB, is required for H2O2 to promote ?
ERK Neg (not) Binding (not) of
4) Confidence 0.06 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.09 Pain Relevance 0
Immunostaining of Erk1 and Erk2 proteins, which operate downstream from Ras, was barely detectable in each of three cell lines examined, and of the three canine hemangiosarcomas cell lines, only "Frog" showed evidence of constitutively active Erk1 and Erk2 based on positive staining by the presence anti-phospho-Erk antibody (Thr 202 and Tyr 204).
Erk2 Spec (examined) Binding (Immunostaining) of associated with hemangiosarcoma
5) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2994824 Disease Relevance 1.13 Pain Relevance 0.04
If , the quantity j has a positive synergy with Akt and ERK.
ERK Binding (synergy) of
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.18 Pain Relevance 0
Conversely, if , the quantity j has a negative synergy with Akt and ERK.
ERK Neg (negative) Binding (synergy) of
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.18 Pain Relevance 0

General Comments

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