INT194807

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.19

nucleus (MAPK1, CREB1, Nfatc1) nucleoplasm (MAPK1, CREB1) mitochondrion (MAPK1, CREB1) DNA binding (MAPK1, Nfatc1) cytoplasm (MAPK1, Nfatc1) signal transduction (MAPK1, CREB1)

Anatomy Link Frequency NFAT 2 MAPK1 (Homo sapiens) CREB1 (Homo sapiens) Nfatc1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 34 94.20 Inflammation 30 77.56 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 31 77.56 Asthma 3 47.44 Thymoma 1 29.12 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Stress 6 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00 Necrosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[70-72]. p38 MAPK can positively and negatively modulate NFAT activity by several mechanisms. p38 MAPK can induce NFAT expression at the transcriptional and post-transcriptional levels and can promote the interaction of NFAT with the coactivator CREB-binding protein (CBP).

p38 MAPK Positive_regulation (promote) of CREB Binding (interaction) of NFAT in NFAT

1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

This test has worked.