INT194814

Context Info Confidence 0.05 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.12

extracellular space (Il4) extracellular region (Il4) plasma membrane (Cd3e) signal transducer activity (Cd3e)

Anatomy Link Frequency T cells 4 Cd3e (Mus musculus) Il4 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 68 69.84 Inflammation 60 5.00 rheumatoid arthritis 8 5.00 Arthritis 6 5.00 Central nervous system 2 5.00 Inflammatory response 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Asthma 6 33.20 INFLAMMATION 62 5.00 Autoimmune Disease 28 5.00 Disease 20 5.00 Hypersensitivity 14 5.00 Stress 12 5.00 Rheumatoid Arthritis 8 5.00 Arthritis 6 5.00 Necrosis 6 5.00 Sepsis 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In murine splenic T cells, CD3-induced and CD3/CD28-induced IL-4 expression as well as CD30-induced IL-13 expression were also partly abrogated by SB203580 [44,46,67].

CD3 Positive_regulation (induced) of Gene_expression (expression) of IL-4 in T cells

1) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.06

In murine splenic T cells, CD3-induced and CD3/CD28-induced IL-4 expression as well as CD30-induced IL-13 expression were also partly abrogated by SB203580 [44,46,67].

CD3 Positive_regulation (induced) of Gene_expression (expression) of IL-4 in T cells

2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.06

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