INT194821

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (MAPK1, Hand2) protein complex (MAPK1, Hand2) nucleus (MAPK1, Hand2)
transcription factor binding (MAPK1, Hand2) cell differentiation (Hand2) nucleoplasm (MAPK1)
MAPK1 (Homo sapiens)
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 100.00 Very High Very High Very High
cytokine 34 82.12 Quite High
headache 1 30.76 Quite Low
Central nervous system 1 9.12 Low Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 100.00 Very High Very High Very High
Hypersensitivity 7 100.00 Very High Very High Very High
Disease 10 95.00 High High
Heart Rate Under Development 2 93.56 High High
Asthma 3 81.40 Quite High
Eosinophilia 1 70.84 Quite High
Autoimmune Disease 14 56.76 Quite High
Acute Coronary Syndrome 2 42.92 Quite Low
Sepsis 3 41.84 Quite Low
Headache 1 30.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations indicate that p38 MAPK is essential for the development of allergic inflammation, probably by controlling Th2 effector functions, and suggest that the p38 MAPK signaling cascade might be an interesting therapeutic target for allergic diseases.
p38 MAPK Regulation (controlling) of Th2 associated with inflammation, hypersensitivity and disease
1) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 1.27 Pain Relevance 0.28

General Comments

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