INT194822

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (MAPK1, Sp1) cytoplasm (MAPK1, Sp1) nucleus (MAPK1, Sp1)
transcription factor binding (MAPK1, Sp1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
MAPK1 (Homo sapiens)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 67.04 Quite High
Inflammation 30 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thymoma 1 54.00 Quite High
Apoptosis 1 32.16 Quite Low
INFLAMMATION 31 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these cells, the inhibition of p38 MAPK affects the activity of the IL-10 promoter by inhibiting binding of the transcription factor Sp1 [81].
Negative_regulation (inhibition) of p38 MAPK Negative_regulation (inhibiting) of Sp1 Binding (binding) of
1) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.10

General Comments

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