INT194837

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.10

nucleus (Camk4, TFAM) mitochondrion (TFAM) signal transduction (Camk4) nucleocytoplasmic transport (Camk4) DNA binding (TFAM) kinase activity (Camk4)

Camk4 (Mus musculus) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 34 82.56 Inflammation 30 5.00 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 1 47.68 Thymoma 1 45.32 INFLAMMATION 31 5.00 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Stress 6 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00 Necrosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The transcription factor CREB can be activated by the calcium/calmodulin-dependent protein kinase IV (CaMKIV) [82] and by the p38 MAPK pathway by means of MK2 or MSK1/2 [40,83].

protein kinase IV Positive_regulation (activated) of transcription factor

1) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.