INT194838

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CREB1, Nfatc1) nucleoplasm (CREB1) signal transduction (CREB1)
mitochondrion (CREB1) nucleolus (CREB1) DNA binding (Nfatc1)
Anatomy Link Frequency
NFAT 1
CREB1 (Homo sapiens)
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 89.76 High High
Inflammation 30 73.12 Quite High
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 73.12 Quite High
Asthma 3 43.00 Quite Low
Thymoma 1 29.12 Quite Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[70-72]. p38 MAPK can positively and negatively modulate NFAT activity by several mechanisms. p38 MAPK can induce NFAT expression at the transcriptional and post-transcriptional levels and can promote the interaction of NFAT with the coactivator CREB-binding protein (CBP).
CREB Binding (interaction) of NFAT in NFAT
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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