INT194846

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.07
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
arms 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 208 100.00 Very High Very High Very High
methotrexate 50 99.98 Very High Very High Very High
Potency 4 96.00 Very High Very High Very High
Inflammation 272 95.28 Very High Very High Very High
Inflammatory response 6 88.80 High High
Pain 60 87.84 High High
adenocard 76 87.48 High High
agonist 15 83.44 Quite High
Antinociceptive 4 81.36 Quite High
cINOD 3 79.92 Quite High
Disease Link Frequency Relevance Heat
Infection 11 98.72 Very High Very High Very High
Targeted Disruption 166 97.68 Very High Very High Very High
Autism 26 95.96 Very High Very High Very High
INFLAMMATION 283 95.28 Very High Very High Very High
Stress 78 91.84 High High
Pain 56 87.84 High High
Apoptosis 4 82.60 Quite High
Rheumatoid Arthritis 4 79.36 Quite High
Immunization 4 77.52 Quite High
Togavirus Infection 1 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, pretreatment with L-NAME, a non-selective NOS inhibitor, augmented the increase of IL-10 in CFA mice.
Positive_regulation (augmented) of Positive_regulation (increase) of IL-10
1) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.53 Pain Relevance 0.70
In addition, we detected for the first time that CFA also induced an upregulation of IL-10.
Positive_regulation (induced) of Positive_regulation (upregulation) of IL-10
2) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.63 Pain Relevance 0.74
The increase of IL-10 was augmented in mice pretreated with 7-NINA or L-NAME, but reduced in mice receiving AG or L-NIO, at 6 and 16 h after CFA (Fig. 4C, P < 0.05 and P < 0.001).


Positive_regulation (augmented) of Positive_regulation (increase) of IL-10
3) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.27 Pain Relevance 0.12
A single injection of LPS caused an elevation of IL-10 in serum from GF, LPS-GF (germfree mice given drinking water containing LPS) and CV mice.
Positive_regulation (caused) of Positive_regulation (elevation) of IL-10
4) Confidence 0.45 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.05
CFA-induced upregulation of IL-10 was increased in 7-NINA pretreated mice, but attenuated in mice receiving AG or L-NIO.
Positive_regulation (increased) of Positive_regulation (upregulation) of IL-10
5) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.58 Pain Relevance 0.74
Children with ASD have increased cytokines of Th2 and Th1 arms of the immune response with Th2 predominant without an increase in IL10 [13].
Positive_regulation (increased) of Neg (without) Positive_regulation (increase) of IL10 in arms associated with cytokine
6) Confidence 0.34 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 1.00 Pain Relevance 0.37
As expected, treatment with methotrexate stimulated IL-10 accumulation in the exudate by 56% in wild-type mice, but significantly decreased IL-10 levels in exudates of A2A-deficient mice.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of IL-10 associated with methotrexate
7) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.93 Pain Relevance 0.70
Sohn et al. showed that the ligation of a C3 complement activation factor (iC3b), which is constitutively present in aqueous humor, stimulates APC upregulation of IL-10 and TGF-?
Positive_regulation (stimulates) of Positive_regulation (upregulation) of IL-10
8) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.24 Pain Relevance 0.17
We hypothesize that primarily increased IL-10 levels account for the reduced anti-bacterial defense after prolonged stressful experience than a reduced inducibility of TNF?
Positive_regulation (account) of Positive_regulation (increased) of IL-10
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.88 Pain Relevance 0.12

General Comments

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