INT194847

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.52
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
leukocyte 4
T cells 4
macrophages 1
monocytes 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 363 98.26 Very High Very High Very High
methotrexate 100 97.62 Very High Very High Very High
Inflammation 260 85.92 High High
Central nervous system 17 76.88 Quite High
cva 3 73.44 Quite High
agonist 47 69.52 Quite High
Inflammatory response 21 63.88 Quite High
antagonist 57 63.12 Quite High
dexamethasone 8 53.20 Quite High
cytokine 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 92 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 12 97.96 Very High Very High Very High
Vibrio Infection 3 88.32 High High
INFLAMMATION 224 85.92 High High
Injury 40 78.40 Quite High
Hemorrhage 3 73.44 Quite High
Adult Respiratory Distress Syndrome 183 71.92 Quite High
Pneumonia 60 42.88 Quite Low
Heart Rate Under Development 3 29.52 Quite Low
Stupor 2 23.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).
Negative_regulation (reduced) of Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate
1) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.47 Pain Relevance 0.66
Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).
Negative_regulation (reduced) of Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate
2) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.40 Pain Relevance 0.59
A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].
Negative_regulation (suppresses) of Positive_regulation (activation) of A2A in T cells
3) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21
A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].
Negative_regulation (suppresses) of in macrophages Positive_regulation (activation) of A2A in T cells
4) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21
A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].
Negative_regulation (suppresses) of in monocytes Positive_regulation (activation) of A2A in T cells
5) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21

General Comments

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