INT194847

Context Info Confidence 0.32 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 4.52 Pain Relevance 1.88

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)

Anatomy Link Frequency leukocyte 4 T cells 4 macrophages 1 monocytes 1 Adora2a (Mus musculus)

Pain Link Frequency Relevance Heat adenocard 363 98.26 methotrexate 100 97.62 Inflammation 260 85.92 Central nervous system 17 76.88 cva 3 73.44 agonist 47 69.52 Inflammatory response 21 63.88 antagonist 57 63.12 dexamethasone 8 53.20 cytokine 32 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 92 99.96 Increased Venous Pressure Under Development 12 97.96 Vibrio Infection 3 88.32 INFLAMMATION 224 85.92 Injury 40 78.40 Hemorrhage 3 73.44 Adult Respiratory Distress Syndrome 183 71.92 Pneumonia 60 42.88 Heart Rate Under Development 3 29.52 Stupor 2 23.60

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).

Negative_regulation (reduced) of Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate

1) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.47 Pain Relevance 0.66

Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).

Negative_regulation (reduced) of Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate

2) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.40 Pain Relevance 0.59

A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].

Negative_regulation (suppresses) of Positive_regulation (activation) of A2A in T cells

3) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21

A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].

Negative_regulation (suppresses) of in macrophages Positive_regulation (activation) of A2A in T cells

4) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21

A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].

Negative_regulation (suppresses) of in monocytes Positive_regulation (activation) of A2A in T cells

5) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21

General Comments

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