INT194848

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.29
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophages 5
monocyte 3
liver 2
T-cell 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 314 100.00 Very High Very High Very High
cytokine 196 100.00 Very High Very High Very High
agonist 24 99.98 Very High Very High Very High
Inflammatory mediators 9 99.68 Very High Very High Very High
adenocard 78 99.64 Very High Very High Very High
Nerve growth factor 2 94.92 High High
Central nervous system 19 92.64 High High
Bile 20 91.40 High High
Pain 17 86.28 High High
methotrexate 50 80.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 373 100.00 Very High Very High Very High
Infection 51 99.30 Very High Very High Very High
Necrosis 13 99.28 Very High Very High Very High
Cancer 92 99.10 Very High Very High Very High
Cytomegalovirus Infection 20 99.10 Very High Very High Very High
Multiple Sclerosis 54 97.12 Very High Very High Very High
Targeted Disruption 73 96.24 Very High Very High Very High
Obstructive Jaundice 14 95.20 Very High Very High Very High
Apoptosis 89 93.76 High High
Immunization 27 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Murine CMV (MCMV) does not encode an IL-10 homolog, although, parallel to the studies of Flano et al. on dendritic cells infected with MHV68 [36] , in vitro MCMV infection of primary macrophages results in secretion of cellular IL-10 and downregulation of MHC II [58].
Negative_regulation (downregulation) of Localization (secretion) of IL-10 in macrophages associated with cytomegalovirus infection and infection
1) Confidence 0.36 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.34 Pain Relevance 0
derived from the activated splenocytes seems to suppress the intestinal secretion of IL-10 from Th2-type lymphocytes and maintain the inflammatory reactions in the liver, particularly during an early period of obstructive jaundice.
Negative_regulation (suppress) of Localization (secretion) of IL-10 in liver associated with inflammation and obstructive jaundice
2) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.53 Pain Relevance 0.23
We do not have a clear explanation for this other than to note it is probable that in the MTX-treated A2A knockout mice there is an imbalance in A1 adenosine receptor function in the absence of A2A, consistent with the previous observation of Hasko and colleagues that an A1 adenosine receptor agonist reduces IL-10 release by lipopolysaccharide-stimulated RAW macrophages [27].
Negative_regulation (reduces) of Localization (release) of IL-10 in macrophages associated with targeted disruption, adenocard and agonist
3) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.05 Pain Relevance 1.00
(Fig. 6, panels A and B), but significantly reduced both IL-10 and IL-4 release (Fig. 6, panels C and D).
Negative_regulation (reduced) of Localization (release) of IL-10
4) Confidence 0.23 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.07
PTx further promotes maturation and functional capacity of antigen presenting cells (APC) [17], increases production and release of pro-inflammatory cytokines such as IL-12 [18] and decreases secretion of anti-inflammatory IL-10 [19].
Negative_regulation (decreases) of Localization (secretion) of IL-10 associated with inflammation and cytokine
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.95 Pain Relevance 0.31
1, IL-10 & IL-4 and suppressed release of pro-inflammatory mediators including TNF-?
Negative_regulation (suppressed) of Localization (release) of IL-10 associated with inflammatory mediators
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832020 Disease Relevance 1.89 Pain Relevance 0.52
Interestingly, some studies have also demonstrated that release of the ‘anti-inflammatory–cytokine, IL-10, is impaired in P2X7????
Negative_regulation (impaired) of Localization (release) of IL-10 associated with inflammation and cytokine
7) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.77 Pain Relevance 0.56
However, TLR4pre inhibited the releases of IL-10 and IFN-?
Negative_regulation (inhibited) of Localization (releases) of IL-10
8) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.14 Pain Relevance 0.08
As noted above, activated macrophages from aged mice and humans produce more prostaglandin E2 than younger individuals, and this proinflammatory coagulation factor suppresses IL-12 secretion, decreases APC surface expression of MHC II, and enhances IL-10 secretion which inhibits T-cell function.
Negative_regulation (inhibits) of Localization (secretion) of IL-10 in T-cell
9) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.41 Pain Relevance 0.24
PK1 triggered the differentiation of both murine and human bone marrow progenitor cells into the monocyte/macrophage lineage [53], and reprogrammed the response of human monocytes to LPS by amplifying IL-12 and tumor necrosis factor alpha (TNF) production, but inhibiting IL-10 release [53].
Negative_regulation (inhibiting) of Localization (release) of IL-10 in monocyte associated with necrosis and cancer
10) Confidence 0.09 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.53 Pain Relevance 0.19
PK1 triggered the differentiation of both murine and human bone marrow progenitor cells into the monocyte/macrophage lineage [53], and reprogrammed the response of human monocytes to LPS by amplifying IL-12 and tumor necrosis factor alpha (TNF) production, but inhibiting IL-10 release [53].
Negative_regulation (inhibiting) of in macrophage Localization (release) of IL-10 in monocyte associated with necrosis and cancer
11) Confidence 0.03 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.53 Pain Relevance 0.19

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