INT194849

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.08
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora3) plasma membrane (Adora3) signal transducer activity (Adora3)
Anatomy Link Frequency
macrophage 2
Adora3 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 132 100.00 Very High Very High Very High
agonist 107 100.00 Very High Very High Very High
Inflammation 89 98.20 Very High Very High Very High
chemokine 2 94.24 High High
antagonist 23 85.16 High High
Arthritis 4 73.52 Quite High
cytokine 10 65.20 Quite High
Central nervous system 2 57.64 Quite High
methotrexate 50 50.00 Quite Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 14 99.84 Very High Very High Very High
INFLAMMATION 89 98.20 Very High Very High Very High
Hypoxia 5 98.16 Very High Very High Very High
Glioblastoma 1 95.84 Very High Very High Very High
Skin Cancer 2 93.20 High High
Targeted Disruption 46 90.92 High High
Arthritis 3 77.28 Quite High
Anaplastic Astrocytoma 3 29.40 Quite Low
Death 1 23.68 Low Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data are in agreement with prior reports showing that adenosine A3 receptor agonists suppress the expression and production of macrophage inflammatory protein 1?
Negative_regulation (suppress) of Gene_expression (agonists) of adenosine A3 receptor in macrophage associated with adenocard, inflammation and agonist
1) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.06 Pain Relevance 1.00
Tumour growth was significantly inhibited after administration of IB-MECA to the animals, paralleled by a decrease in A3R expression in tumour lesions.
Negative_regulation (decrease) of Gene_expression (expression) of A3R associated with cancer
2) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 1.02 Pain Relevance 0.28

General Comments

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