INT194850

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 20.57
Pain Relevance 13.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Anatomy Link Frequency
mast cells 3
lung 2
GMC 2
neutrophils 2
urinary bladder 1
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2820 100.00 Very High Very High Very High
Potency 626 99.96 Very High Very High Very High
chemokine 21 99.60 Very High Very High Very High
Neuropathic pain 5 99.46 Very High Very High Very High
agonist 2026 99.44 Very High Very High Very High
fibrosis 79 99.08 Very High Very High Very High
cytokine 143 99.00 Very High Very High Very High
Pain 63 98.88 Very High Very High Very High
antinociception 1 98.84 Very High Very High Very High
Inflammatory response 32 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 33 99.60 Very High Very High Very High
Neuropathic Pain 19 99.46 Very High Very High Very High
Hypoxia 98 99.40 Very High Very High Very High
Cystic Fibrosis 72 99.08 Very High Very High Very High
Pain 67 98.88 Very High Very High Very High
Lung Injury 30 98.84 Very High Very High Very High
Asthma 67 98.40 Very High Very High Very High
Apoptosis 56 98.40 Very High Very High Very High
INFLAMMATION 697 98.28 Very High Very High Very High
Diarrhoea 24 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with previous work showing selective A2BAR induction with vascular hypoxia [24] or myocardial IP [28], these studies reveal induction of A2BAR transcript and protein with renal IP treatment.


Positive_regulation (induction) of A2BAR associated with hypoxia
1) Confidence 0.61 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.28 Pain Relevance 0.06
In addition, Western blot analysis of A2BAR protein from preconditioned renal tissues confirmed A2BAR induction (Figure 9E).
Positive_regulation (induction) of A2BAR
2) Confidence 0.61 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.06
These pharmacological studies confirm the critical role of A2BAR signaling for renal protection by IP.


Positive_regulation (role) of A2BAR
3) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.50 Pain Relevance 0.38
These compounds represent, to the best of our knowledge, the first report about adenosine-related structures capable of activating hA2B AR subtype in the very low nanomolar range.
Positive_regulation (activating) of A2B associated with adenocard
4) Confidence 0.49 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.28
The presence of the chlorine atom at the 2-position of the purine nucleus did not seem to affect the ability of the tested compounds to activate hA2B AR, as is clear from the comparison of chlorinated derivatives 23 (hA2B EC50?
Positive_regulation (activate) of A2B in nucleus
5) Confidence 0.49 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.04
Consistent with previous work showing selective A2BAR induction with vascular hypoxia [24] or myocardial IP [28], these studies reveal induction of A2BAR transcript and protein with renal IP treatment.


Positive_regulation (induction) of A2BAR associated with hypoxia
6) Confidence 0.47 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.28 Pain Relevance 0.06
These studies revealed prompt and selective induction of the A2BAR transcript following renal IP (approximately 6-fold induction 60 min after IP, p < 0.05, Figure 9C).
Positive_regulation (induction) of A2BAR
7) Confidence 0.47 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.08
NECA stimulated cAMP accumulation in both hA2BHEK 293 and native cells, whereas phospholipase C activation was observed in recombinant receptors and endogenous subtypes expressed in neutrophils but not in lymphocytes.
Positive_regulation (accumulation) of A2B in neutrophils
8) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.16 Pain Relevance 0.26
Activation of cardiac A2B AR receptors at reperfusion showed to be protective in the rabbit, but because of the very low affinity of the receptors, endogenous cardiac adenosine is unable to elicit their signalling.
Positive_regulation (Activation) of A2B associated with adenocard
9) Confidence 0.42 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.73 Pain Relevance 0.52
Activation of A2B AR subtype would moreover increase production of the anti-inflammatory cytokine IL-10 [50].
Positive_regulation (Activation) of A2B associated with inflammation and cytokine
10) Confidence 0.42 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.87 Pain Relevance 0.41
A2B was upregulated in response to a 'lung-destructive' ventilation strategy in rats, whereas its expression level remained unchanged with lung-protective ventilation [34].
Positive_regulation (upregulated) of A2B in lung
11) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.34 Pain Relevance 0.44
A2B is coupled to both Gs and Gq proteins, activating adenylate cyclase and phospholipase C, respectively.
Positive_regulation (activating) of A2B
12) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.76 Pain Relevance 0.35
In contrast to the other ARs, A2B activation requires adenosine concentrations that are not reached under physiological conditions.
Positive_regulation (activation) of A2B associated with adenocard
13) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.81 Pain Relevance 0.39
On the basis of the above studies showing induction of the renal A2BAR with preconditioning, we were interested to define, which tissues express the A2BAR within the kidneys.
Positive_regulation (induction) of A2BAR
14) Confidence 0.41 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.23 Pain Relevance 0.03
Therapeutic potential of A2B adenosine receptor agonists
Positive_regulation (potential) of A2B associated with adenocard and agonist
15) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.89 Pain Relevance 0.61
In particular, participation of A2B ARs in the analgaesic effects mediated by caffeine in an acute animal model of nociception (hot-plate test) has been documented [41].
Positive_regulation (participation) of A2B associated with nociception
16) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.71 Pain Relevance 0.63
Activation of A2B AR implies stimulation of adenylate cyclase and activation of phospholipase C through the coupling to Gs and Gq/11 proteins, respectively.
Positive_regulation (Activation) of A2B
17) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.18 Pain Relevance 0.32
In particular, the gain in A2B AR selectivity promoted in these new agonists would provide useful pharmacological probes for exploring the role of in vivo receptor activation, and thus a more complete insight of the prospective employment of A2B AR ligands in clinical therapy might be offered.
Positive_regulation (promoted) of A2B associated with agonist
18) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.13 Pain Relevance 0.27
128 nM) and an improved binding profile in comparison with NECA and (S)-PHP-NECA in activating A2B AR, (hA1Ki /hA2B EC50?
Positive_regulation (activating) of A2B
19) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.08 Pain Relevance 0.35
In particular, the gain in A2B AR selectivity promoted in these new agonists would provide useful pharmacological probes for exploring the role of in vivo receptor activation, and thus a more complete insight of the prospective employment of A2B AR ligands in clinical therapy might be offered.
Positive_regulation (employment) of A2B associated with agonist
20) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.11 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox