INT194854

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.55
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
skin 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 125 100.00 Very High Very High Very High
adenocard 73 99.84 Very High Very High Very High
methotrexate 50 99.80 Very High Very High Very High
cytokine 53 98.56 Very High Very High Very High
Multiple sclerosis 63 98.20 Very High Very High Very High
rheumatoid arthritis 8 97.36 Very High Very High Very High
Demyelination 12 80.28 Quite High
Spinal cord 2 74.12 Quite High
Pain 15 63.60 Quite High
Thermal hyperalgesia 18 59.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 127 100.00 Very High Very High Very High
Demyelinating Disease 85 98.20 Very High Very High Very High
Rheumatoid Arthritis 8 97.36 Very High Very High Very High
Targeted Disruption 76 90.08 High High
Multiple Sclerosis 35 81.08 Quite High
Death 5 80.72 Quite High
Schizophrenia 1 71.32 Quite High
Disease 13 70.76 Quite High
Pain 14 63.60 Quite High
Hyperalgesia 33 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
gene expression and has a differential effect on the increase of IL-10 in plantar skin after CFA
Regulation (effect) of Positive_regulation (increase) of IL-10 in skin
1) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.23 Pain Relevance 0.28
through induction of IDO and IL-10, the latter of which exerts its effects in
Regulation (effects) of Positive_regulation (induction) of IL-10
2) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.18 Pain Relevance 0.39
Since adenosine receptor activation modulates the release of IL-10 by different inflammatory cells [25-27] and methotrexate-treated rheumatoid arthritis patients have shown increased serum levels of this cytokine [28,29], we determined whether constitutively or methotrexate-modified IL-10 accumulation in the inflammatory exudate was altered in adenosine receptor-deficient mice.
Regulation (altered) of Positive_regulation (accumulation) of IL-10 associated with adenocard, inflammation, rheumatoid arthritis, methotrexate and cytokine
3) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.15 Pain Relevance 0.77

General Comments

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