INT194859

Context Info Confidence 0.52 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.86 Pain Relevance 0.33

extracellular space (IL1B, MMP13) extracellular region (IL1B, MMP13) aging (IL1B) Golgi apparatus (MMP13) cell-cell signaling (IL1B) cytosol (IL1B)

Anatomy Link Frequency chondrocytes 2 IL1B (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 195 97.36 rheumatoid arthritis 15 92.96 Inflammation 27 90.08 Arthritis 6 53.76 metalloproteinase 14 50.00 agonist 2 50.00 cytokine 21 35.96 Inflammatory mediators 1 34.96 Pain 17 5.00 imagery 11 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 195 97.36 Rheumatoid Arthritis 15 92.96 INFLAMMATION 29 90.08 Osteophyte 4 85.64 Stress 1 70.96 Arthritis 11 53.76 Cancer 6 50.40 Necrosis 5 49.84 Toxicity 1 45.52 Disease 38 5.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

reduced expression of both constructs, which does not reflect the response of endogenous MMP-1 and MMP-13, whose expression is induced by IL-1?

IL-1 Positive_regulation (induced) of Gene_expression (expression) of MMP-13

1) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

It was recently reported that phenyl N-tert-butylnitrone, a spin-trap agent, downregulates IL-1-induced MMP-13 expression via the inhibition of the c-Jun amino-terminal kinase pathway in OA chondrocytes [61].

IL-1 Positive_regulation (induced) of Gene_expression (expression) of MMP-13 in chondrocytes associated with osteoarthritis

2) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.86 Pain Relevance 0.33

General Comments

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