INT194861

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.55
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1B, IL1R1) aging (IL1B) intracellular (IL1R1)
signal transducer activity (IL1R1) cell-cell signaling (IL1B) cytosol (IL1B)
Anatomy Link Frequency
endothelial cells 1
IL1B (Homo sapiens)
IL1R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 99.22 Very High Very High Very High
cytokine 199 98.16 Very High Very High Very High
chemokine 2 97.60 Very High Very High Very High
Inflammation 138 92.96 High High
Inflammatory response 32 81.16 Quite High
Osteoarthritis 190 74.36 Quite High
rheumatoid arthritis 10 66.68 Quite High
anakinra 1 59.80 Quite High
agonist 3 58.16 Quite High
Arthritis 3 24.32 Low Low
Disease Link Frequency Relevance Heat
Adhesions 4 96.00 Very High Very High Very High
INFLAMMATION 175 92.96 High High
Osteoarthritis 190 74.36 Quite High
Injury 35 73.76 Quite High
Disease 48 69.24 Quite High
Rheumatoid Arthritis 10 66.68 Quite High
Systemic Inflammatory Response Syndrome 2 61.32 Quite High
Cancer 10 55.92 Quite High
Necrosis 8 55.36 Quite High
Burns 2 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After binding to IL-1R, IL-1 induces the production of a high spectrum of cytokines and chemokines as well as the expression of adhesion molecules on endothelial cells, thus leading to the recruitment of inflammatory cells.
IL-1 Binding (binding) of IL-1R in endothelial cells associated with chemokine, inflammation, adhesions and cytokine
1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.75 Pain Relevance 0.55
IL-1R antagonist (IL-1Ra) is a structural homologue of IL-1 that binds to IL-1R but does not induce any cellular responses and is therefore a natural inhibitor of IL-1 activity [93].
IL-1 Binding (binds) of IL-1R associated with antagonist
2) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.48 Pain Relevance 0.38
Type II sIL-1R binds IL-1?
IL-1 Binding (binds) of sIL-1R
3) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.32 Pain Relevance 0.26

General Comments

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