INT194863

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.23
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R1, IL1RN) plasma membrane (IL1R1, IL1RN) intracellular (IL1R1, IL1RN)
extracellular space (IL1RN) nucleus (IL1RN) cytoplasm (IL1RN)
IL1R1 (Homo sapiens)
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 100.00 Very High Very High Very High
cytokine 66 99.98 Very High Very High Very High
Inflammation 97 85.96 High High
anakinra 9 81.76 Quite High
Inflammatory response 2 79.08 Quite High
Osteoarthritis 570 78.92 Quite High
rheumatoid arthritis 37 71.24 Quite High
agonist 3 62.72 Quite High
substance P 8 54.72 Quite High
fibrosis 1 43.84 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 12 87.32 High High
INFLAMMATION 105 85.96 High High
Coronary Artery Disease 7 83.44 Quite High
Acute Coronary Syndrome 42 81.36 Quite High
Osteoarthritis 570 78.92 Quite High
Disease 117 73.80 Quite High
Rheumatoid Arthritis 38 71.24 Quite High
Neurodegenerative Disease 1 71.12 Quite High
Injury 49 62.00 Quite High
Cancer 15 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that signal via the Type 1 IL-1 receptor and there is a specific Interleukin-1 receptor antagonist (IL-1ra), the only known naturally occurring cytokine antagonist, that inhibits IL-1 actions by binding to the Type 1 IL-1 Receptor (IL-1RI), blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].


IL-1 Binding (binding) of antagonist associated with antagonist and cytokine
1) Confidence 0.09 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.10 Pain Relevance 0.55
However, IL-1Ra also binds the sIL-1R, and the binding affinity of sIL1R to both IL-1 isoforms and IL-1Ra differs.
sIL-1R Binding (binds) of IL-1Ra
2) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.22 Pain Relevance 0.27
more readily than IL-1Ra; in contrast, type I sIL-1R binds IL-1Ra with high affinity [46-48].
sIL-1R Binding (binds) of IL-1Ra
3) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.32 Pain Relevance 0.23
However, IL-1Ra also binds the sIL-1R, and the binding affinity of sIL1R to both IL-1 isoforms and IL-1Ra differs.
sIL1R Binding (affinity) of IL-1Ra
4) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.32 Pain Relevance 0.27
The IL-1R antagonist (IL-1ra) is naturally occurring and binds to the IL-1RI.
IL-1R Binding (binds) of IL-1RI associated with antagonist
5) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727904 Disease Relevance 0.25 Pain Relevance 0.33

General Comments

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