INT194892

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.93
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
cartilage 2
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 227 100.00 Very High Very High Very High
metalloproteinase 131 100.00 Very High Very High Very High
Inflammation 111 89.08 High High
Inflammatory response 11 88.20 High High
cytokine 58 82.32 Quite High
Arthritis 78 79.04 Quite High
cINOD 4 73.28 Quite High
Osteoarthritis 39 66.80 Quite High
methotrexate 21 63.52 Quite High
COX-2 inhibitor 2 59.20 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 283 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 36 99.26 Very High Very High Very High
Chronic Lymphoid Leukemia 1 97.40 Very High Very High Very High
INFLAMMATION 130 96.80 Very High Very High Very High
Arthritis 82 79.04 Quite High
Disease 41 71.76 Quite High
Anaplastic Astrocytoma 1 69.92 Quite High
Osteoarthritis 37 66.80 Quite High
Apoptosis 31 59.92 Quite High
Insulin Resistance 1 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that inhibition of MMP-1 by ribozymes has a protective effect on cartilage erosion in the SCID mouse co-implantation model.14 Both MMP-1 and MMP-13 contribute to the process of cartilage destruction in RA and can therefore be targeted for treatment.
Regulation (contribute) of MMP-1 in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
1) Confidence 0.22 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.19 Pain Relevance 0.41
It has been shown that inhibition of MMP-1 by ribozymes has a protective effect on cartilage erosion in the SCID mouse co-implantation model.14 Both MMP-1 and MMP-13 contribute to the process of cartilage destruction in RA and can therefore be targeted for treatment.
Regulation (targeted) of MMP-1 in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
2) Confidence 0.22 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.20 Pain Relevance 0.41
Inhibition of MMP-1 synthesis by retroviral over-expression of ribozymes that target MMP-1 mRNA resulted in a significant reduction of the invasiveness of RASFs in the SCID mouse model for RA [15], without affecting the production of other MMPs.
Regulation (target) of MMP-1 associated with severe combined immunodeficiency, metalloproteinase and rheumatoid arthritis
3) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.86 Pain Relevance 0.78
A ribozyme was also utilized to target MMP-1 in the same model [85].
Regulation (target) of MMP-1
4) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.43 Pain Relevance 0.21
The concentrations of MMP-1 and vascular endothelial growth factor (VEGF) in the culture supernatants were measured using the Biotrak human MMP-1 ELISA system (Amarsham Pharmacia Biotech, Buckinghamshire, UK) and human VEGF immunoassay kit (BioSource International, Camarillo, CA, USA), respectively.
Regulation (concentrations) of MMP-1 associated with metalloproteinase
5) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.20 Pain Relevance 0.30
including MMP-1 and MMP-13 appeared to be influenced by RA as well [59].


Regulation (influenced) of MMP-1 associated with rheumatoid arthritis and metalloproteinase
6) Confidence 0.02 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.06 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox