INT194896

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.65
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mfi2) extracellular region (Mfi2) plasma membrane (Mfi2)
Anatomy Link Frequency
macrophages 3
Monocyte 1
embryonic stem cells 1
EL4 1
peritoneal macrophages 1
Mfi2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 93 100.00 Very High Very High Very High
rheumatoid arthritis 181 95.60 Very High Very High Very High
Osteoarthritis 17 91.92 High High
Inflammatory response 36 91.20 High High
cytokine 126 86.20 High High
Inflammation 101 70.88 Quite High
methotrexate 18 66.96 Quite High
chemokine 35 50.00 Quite Low
metalloproteinase 19 31.20 Quite Low
cva 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 100.00 Very High Very High Very High
Cv Unclassified Under Development 35 100.00 Very High Very High Very High
Hypersensitivity 26 99.46 Very High Very High Very High
Rheumatoid Arthritis 200 95.60 Very High Very High Very High
Lung Injury 35 95.60 Very High Very High Very High
Cv General 4 Under Development 45 94.88 High High
Adult Respiratory Distress Syndrome 210 93.40 High High
Osteoarthritis 17 91.92 High High
Cancer 185 91.48 High High
INFLAMMATION 136 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(MFI: 85.28, (IgG: 49.23)) than did ischemia-activated macrophages (MFI: 104.03 (IgG: 46.06)) whereas LPS-stimulated peritoneal macrophages expressed higher levels of TNF-a (MFI: 53.84, (IgG: 14.79)) than did ischemia-activated macrophages (MFI: 39.28 (IgG: 24.11)).


Gene_expression (expressed) of MFI in macrophages associated with ischemia
1) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.27 Pain Relevance 0.21
Generation of MFI values for TNF-?
Gene_expression (Generation) of MFI
2) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
, and that the MFI levels of TNF-?
Gene_expression (levels) of MFI
3) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.06 Pain Relevance 0.11
MFI: 27 ± 2) than do macrophages (IL-1?
Gene_expression (do) of MFI in macrophages
4) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.11 Pain Relevance 0.06
Determination of the MFI showed that the LPS-stimulated peritoneal macrophages expressed lower levels of IL-1?
Gene_expression (Determination) of MFI in peritoneal macrophages
5) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.25 Pain Relevance 0.21
(MFI: 85.28, (IgG: 49.23)) than did ischemia-activated macrophages (MFI: 104.03 (IgG: 46.06)) whereas LPS-stimulated peritoneal macrophages expressed higher levels of TNF-a (MFI: 53.84, (IgG: 14.79)) than did ischemia-activated macrophages (MFI: 39.28 (IgG: 24.11)).


Gene_expression (expressed) of MFI in macrophages associated with ischemia
6) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.27 Pain Relevance 0.21
Both mAb bound 7-AAD+ EL4 cells but only the mean fluorescence intensity (MFI) of DAB4 binding significantly increased with time post-chemotherapy whereas TNT1 MFI declined significantly over time (data not shown).
Gene_expression (declined) of MFI in EL4
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645682 Disease Relevance 1.03 Pain Relevance 0
Monocyte populations were gated using FSC/SSC and anti-CD14PE, and CD36 MFI determined using a BD FACS Canto Flow Cytometer.
Spec (determined) Gene_expression (determined) of MFI in Monocyte associated with hypersensitivity
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.20 Pain Relevance 0.05
B1 (p50) protein, the quantity of which can be expressed as MFI.
Gene_expression (expressed) of MFI
9) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.73 Pain Relevance 0.46
The tissue distribution and expression levels of hTF in transgenic mice were similar to that of mTF in wild type mice, and no mTF expression was detected in the transgenic mice [16].
Gene_expression (expression) of mTF associated with targeted disruption
10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.45 Pain Relevance 0
Chimeric mice derived from targeted 129SvBrd embryonic stem cells were bred with C57BL/6 mice to produce hTF/mTF heterozygous mice and the breeding colony was established by further backcrossing with C57BL/6 mice. hTFKI homozygous mice (hTF/hTF) and wild type littermates used in this study were derived from breeding N2 heterozygous mice.
Gene_expression (produce) of mTF in embryonic stem cells
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.77 Pain Relevance 0.07
The tissue distribution and expression levels of hTF in transgenic mice were similar to that of mTF in wild type mice, and no mTF expression was detected in the transgenic mice [16].
Gene_expression (expression) of mTF associated with targeted disruption
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.44 Pain Relevance 0
As a result, expression of mTF was completely disrupted and hTF was expressed under the control of mTF promoter.
Gene_expression (expression) of mTF
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.78 Pain Relevance 0.08
However instead of using non-human primates, we developed human TF knock-in (hTF-KI) transgenic mice, which express human TF instead of murine TF (mTF).
Gene_expression (express) of mTF associated with targeted disruption
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.13 Pain Relevance 0.15

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