INT194901

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.76
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
B-cell 3
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 154 98.20 Very High Very High Very High
addiction 4 98.02 Very High Very High Very High
cva 3 95.92 Very High Very High Very High
cytokine 55 93.28 High High
Inflammation 95 87.64 High High
Inflammatory mediators 16 85.24 High High
Inflammatory response 23 58.08 Quite High
metalloproteinase 38 46.08 Quite Low
methotrexate 32 40.60 Quite Low
chemokine 34 38.96 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 15 99.44 Very High Very High Very High
Rheumatoid Arthritis 154 98.20 Very High Very High Very High
Hemorrhage 3 95.92 Very High Very High Very High
Motor Neuron Diseases 107 95.60 Very High Very High Very High
Injury 54 95.32 Very High Very High Very High
Necrosis 16 94.28 High High
Epstein-barr Virus 52 92.48 High High
Lymphatic System Cancer 12 90.72 High High
Targeted Disruption 64 90.12 High High
Lymphoproliferative Disease 8 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activation associated with hepatic cell apoptosis and proliferation, but its effect on NF-?
Regulation (effect) of NF associated with apoptosis
1) Confidence 0.21 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.36 Pain Relevance 0.27
The down-regulation of all three NF subunits observed in this study would be detrimental according to either interpretation of NF involvement in ALS pathology, first by interfering with their stoichiometric balance and second by depleting their availability as a potential buffer for aberrant enzymatic activities.


Regulation (regulation) of NF associated with motor neuron diseases
2) Confidence 0.11 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.05 Pain Relevance 0
At this point, it is unclear whether the diminished levels of latency in the non–B-cell population reflect a dependence on B-cell latency for establishment of latency in the non–B-cell reservoirs or whether there is a role for NF-?
Spec (whether) Regulation (role) of NF in B-cell associated with addiction
3) Confidence 0.11 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.06 Pain Relevance 0.05
B plays in B-cell biology, lymphotropic gammaherpesviruses have evolved multiple strategies to modulate NF-?
Regulation (modulate) of NF in B-cell
4) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.52 Pain Relevance 0.07
HV68 modulates NF-?
Regulation (modulates) of NF
5) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.57 Pain Relevance 0.09
B transcription factors are a family of cellular proteins that play an important role regulating gene expression in B cells, and it has been shown that gammaherpesviruses have evolved multiple strategies for manipulating NF-?
Regulation (manipulating) of NF in B cells
6) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1781481 Disease Relevance 0.78 Pain Relevance 0
Effect of CpG-ODN on NF-?
Regulation (Effect) of NF
7) Confidence 0.06 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.44 Pain Relevance 0.19
Effect of silencing mRNA for NF?
Regulation (Effect) of NF
8) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.54 Pain Relevance 0.27
It is possible, therefore, that the up-regulation of NF?
Regulation (regulation) of NF
9) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.44 Pain Relevance 0.22

General Comments

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