INT194905

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 11.87
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
bone marrow 2
bands 2
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1078 99.04 Very High Very High Very High
Osteoarthritis 238 98.90 Very High Very High Very High
Inflammation 112 98.80 Very High Very High Very High
cytokine 60 98.60 Very High Very High Very High
metalloproteinase 266 94.56 High High
methotrexate 224 91.80 High High
Central nervous system 26 84.72 Quite High
anesthesia 17 46.24 Quite Low
cINOD 16 24.88 Low Low
Inflammatory mediators 12 23.88 Low Low
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Infection 152 99.34 Very High Very High Very High
Rheumatoid Arthritis 1078 99.04 Very High Very High Very High
Osteoarthritis 238 98.90 Very High Very High Very High
INFLAMMATION 147 98.80 Very High Very High Very High
Cytomegalovirus Infection 6 96.88 Very High Very High Very High
Congenital Anomalies 60 96.48 Very High Very High Very High
Recurrence 28 93.96 High High
Arthritis 28 81.20 Quite High
Injury 7 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HV68 at a multiplicity of infection (MOI) of 1 or 10 for 6 h followed by transfection with an NF-?
Positive_regulation (transfection) of Gene_expression (transfection) of NF associated with infection
1) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.37 Pain Relevance 0
B activation, arguing against interference with NF-?
Positive_regulation (activation) of Gene_expression (arguing) of NF
2) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.55 Pain Relevance 0
Since we observed significant NF-?
Positive_regulation (observed) of Gene_expression (observed) of NF
3) Confidence 0.07 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.54 Pain Relevance 0.19
The data indicate that the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.60 Pain Relevance 0.33
These results indicate that the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526601 Disease Relevance 0.48 Pain Relevance 0.38
For example, the assembly of paranodal axoglial junctions (appearing as transverse bands in freeze-fracture replicas) requires association of the adhesion protein neurofascin-155 expressed by oligodendrocytes with the axonal caspr-contactin heteromer (Charles et al., 2002).
Positive_regulation (requires) of Gene_expression (expressed) of neurofascin-155 in bands associated with adhesions
6) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0.10 Pain Relevance 0.08
It should be also noted that the expression of NF?
Positive_regulation (noted) of Gene_expression (expression) of NF
7) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.77 Pain Relevance 0.59
might result from abnormal expression of NF?
Spec (might) Positive_regulation (result) of Gene_expression (expression) of NF
8) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.94 Pain Relevance 0.49
B1 mRNA was significantly higher in RA bone marrow CD34+ cells than in OA bone marrow CD34+ cells (p = 0.005351), whereas there were no significant differences in the expression of NF?
Neg (no) Positive_regulation (were) of Gene_expression (expression) of NF in bone marrow associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.63 Pain Relevance 0.41
Relevance of expression of NF?
Positive_regulation (Relevance) of Gene_expression (expression) of NF
10) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.73 Pain Relevance 0.52
Relevance of the expression of NF?
Positive_regulation (Relevance) of Gene_expression (expression) of NF
11) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.82 Pain Relevance 0.58
resulted in the increased expression of NF?
Positive_regulation (increased) of Gene_expression (expression) of NF
12) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.45 Pain Relevance 0.22
The present study has revealed the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
13) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 1.10 Pain Relevance 0.46
It is possible that the enhanced expression of NF?
Spec (possible) Positive_regulation (enhanced) of Gene_expression (expression) of NF
14) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 1.16 Pain Relevance 0.40
The data suggest that the increased expression of NF?
Positive_regulation (increased) of Gene_expression (expression) of NF
15) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.91 Pain Relevance 0.46
The data suggest, therefore, that the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
16) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.75 Pain Relevance 0.45
Taken together, these data strongly suggest that the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
17) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.39 Pain Relevance 0.19
These results confirm that the enhanced expression of NF?
Positive_regulation (enhanced) of Gene_expression (expression) of NF
18) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.58 Pain Relevance 0.44

General Comments

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