INT194913

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.91
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
nodes 2
bone marrow 1
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.6 4 100.00 Very High Very High Very High
metalloproteinase 134 99.16 Very High Very High Very High
Inflammation 120 97.44 Very High Very High Very High
cytokine 69 97.36 Very High Very High Very High
Osteoarthritis 119 96.92 Very High Very High Very High
rheumatoid arthritis 540 96.48 Very High Very High Very High
potassium channel 32 91.04 High High
sodium channel 8 90.72 High High
methotrexate 112 86.56 High High
Inflammatory response 17 73.20 Quite High
Disease Link Frequency Relevance Heat
Infection 304 99.34 Very High Very High Very High
Diabetes Mellitus 156 99.24 Very High Very High Very High
INFLAMMATION 162 97.44 Very High Very High Very High
Osteoarthritis 119 96.92 Very High Very High Very High
Stress 2 96.92 Very High Very High Very High
Rheumatoid Arthritis 540 96.48 Very High Very High Very High
Arthritis 15 96.08 Very High Very High Very High
Injury 54 94.80 High High
Primary Effusion Lymphoma 4 94.40 High High
Adhesions 12 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, bacteria, and viruses can release NF-?
Localization (release) of NF
1) Confidence 0.36 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.41 Pain Relevance 0.27
B1 gene is significantly increased in T1D adults, and an association of the AA genotype of NF-?
Localization (genotype) of NF associated with diabetes mellitus
2) Confidence 0.29 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.80 Pain Relevance 0
B molecules and translocation of NF-?
Localization (translocation) of NF
3) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.50 Pain Relevance 0.09
B activation, (ii) the establishment of virus infection in cell populations that do not rely on NF-?
Neg (not) Localization (rely) of NF associated with infection
4) Confidence 0.15 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.32 Pain Relevance 0
Thus, it is likely that manipulation of NF-?
Localization (manipulation) of NF
5) Confidence 0.15 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.50 Pain Relevance 0
M might reflect (i) the utilization of alternative NIK/IKK1-mediated NF-?
Localization (utilization) of NF
6) Confidence 0.15 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.33 Pain Relevance 0
CpG-ODN also induced nuclear translocation of NF-?
Localization (translocation) of NF
7) Confidence 0.11 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2761862 Disease Relevance 0.96 Pain Relevance 0.32
B ligand (RANKL)/receptor activator of nuclear factor (NF)?
Localization (factor) of NF
8) Confidence 0.07 Published 2007 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2248226 Disease Relevance 0.81 Pain Relevance 0.12
In addition, neurofascin-186 and Nav1.6 channels are localized to nodes of Ranvier (Fig. 4, e, f, i, and j) and caspr, and neurofascin-155 and band 4.1 are appropriately localized at paranodes (Fig. 4, k–n).
Localization (localized) of neurofascin-186 in nodes associated with nav1.6
9) Confidence 0.07 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.30
In addition, neurofascin-186 and Nav1.6 channels are localized to nodes of Ranvier (Fig. 4, e, f, i, and j) and caspr, and neurofascin-155 and band 4.1 are appropriately localized at paranodes (Fig. 4, k–n).
Localization (localized) of neurofascin-155 in nodes associated with nav1.6
10) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.26
Since bee venom and melittin delay and reduce nuclear translocation of the p50 subunit of NF?
Localization (translocation) of NF
11) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.90 Pain Relevance 0.50
B plays an important role in inhibition of translocation of NF?
Localization (translocation) of NF
12) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.70 Pain Relevance 0.41
B related genes through upregulation of the translocation of NF?
Localization (translocation) of NF
13) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.62 Pain Relevance 0.34
B but not p65 (RelA) [10], the importance of NF?
Localization (importance) of NF
14) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.90 Pain Relevance 0.50
Purified bone marrow CD34+ cells (obtained from three RA patients and three OA patients) were treated with IntraPrep™ Permeabilization Reagent (Immunotech, Marseille, France), followed by staining with phycoerythrin (PE)-conjugated anti-NF?
Localization (anti) of NF in bone marrow associated with rheumatoid arthritis and osteoarthritis
15) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.19 Pain Relevance 0.10
B1), 6 seconds (NF?
Localization (seconds) of NF
16) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.18 Pain Relevance 0.09
It should be noted that NF?
Localization (noted) of NF
17) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.79 Pain Relevance 0.48

General Comments

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