INT194933

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD22) plasma membrane (CD22)
Anatomy Link Frequency
plasma 1
B-cells 1
CD22 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 11 82.68 Quite High
corticosteroid 13 5.00 Very Low Very Low Very Low
Antihistamine 7 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Paracetamol 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 31 98.52 Very High Very High Very High
Disease 43 89.24 High High
Rheumatoid Arthritis 11 82.68 Quite High
Apoptosis 3 78.24 Quite High
Hodgkin's Disease 9 70.68 Quite High
Systemic Lupus Erythematosus 66 65.08 Quite High
Syndrome 6 63.04 Quite High
Adhesions 3 47.44 Quite Low
Solid Tumor 2 33.68 Quite Low
Increased Venous Pressure Under Development 3 10.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting CD22 as a strategy for treating systemic autoimmune diseases

B-cells play an important role in the diagnosis and to some extent the pathogenesis of many autoimmune diseases.

Positive_regulation (Targeting) of CD22 in B-cells associated with autoimmune disease
1) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC2376077 Disease Relevance 0.63 Pain Relevance 0.04
It has been reported that this effect of CD22 is mediated by potentiation of plasma membrane calcium-ATPase and requires SHP-1 [37].
Positive_regulation (requires) of CD22 in plasma
2) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.08 Pain Relevance 0

General Comments

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