INT194939

Context Info Confidence 0.18 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK) cytoplasm (SYK)

SYK (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 1 13.44 corticosteroid 6 5.00 Antihistamine 4 5.00 cINOD 3 5.00 Paracetamol 3 5.00 tolerance 3 5.00 methotrexate 2 5.00 depression 2 5.00 Central nervous system 1 5.00 cytokine 1 5.00

Disease Link Frequency Relevance Heat Adhesions 1 73.40 Systemic Lupus Erythematosus 43 65.24 Autoimmune Disease 9 61.04 Disease 32 39.32 Increased Venous Pressure Under Development 2 36.16 Nephritis 3 35.56 Apoptosis 1 32.48 Renal Disease 1 30.88 Renal Failure 1 17.12 Arthritis 1 13.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SHP-1 is a tyrosine phosphatase that negatively regulates several intracellular signaling pathways, including the calcium pathway, through dephosphorylation of signaling intermediates, such as Lyn and Syk.

Regulation (regulates) of Phosphorylation (dephosphorylation) of Syk

1) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.