INT19494

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pomc, Ins1) extracellular region (Pomc, Ins1) cytoplasm (Pomc, Ins1)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) carbohydrate metabolic process (Ins1)
Pomc (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 98.60 Very High Very High Very High
antagonist 1 98.24 Very High Very High Very High
opiate 3 97.44 Very High Very High Very High
Enkephalin 6 85.28 High High
Dynorphin 5 79.72 Quite High
agonist 2 76.52 Quite High
Opioid 2 67.12 Quite High
Disease Link Frequency Relevance Heat
Obesity 5 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, beta-endorphin at the high dose levels of 16 and 64 nmol/kg augmented the glucose- and terbutaline-induced insulin secretion (p less than 0.05).
beta-endorphin Positive_regulation (augmented) of Localization (secretion) of insulin
1) Confidence 0.62 Published 1989 Journal Int. J. Pancreatol. Section Abstract Doc Link 2574736 Disease Relevance 0 Pain Relevance 0.93
Beta-endorphin (10(-8)M) enhanced insulin release from isolated ob/ob and lean mouse islets incubated in medium containing 6 mM glucose, but inhibited release when 20 mM glucose was present.
Beta-endorphin Positive_regulation (enhanced) of Localization (release) of insulin
2) Confidence 0.41 Published 1991 Journal Peptides Section Abstract Doc Link 2067974 Disease Relevance 0.38 Pain Relevance 0.09

General Comments

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