INT194944

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PTPN6) cell proliferation (PTPN6) cytosol (PTPN6)
nucleus (PTPN6) cytoplasm (PTPN6)
Anatomy Link Frequency
plasma 1
B cell 1
PTPN6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 2 17.64 Low Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Antihistamine 8 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 78.72 Quite High
Adhesions 2 77.60 Quite High
Systemic Lupus Erythematosus 86 69.44 Quite High
Autoimmune Disease 18 65.24 Quite High
Disease 64 43.52 Quite Low
Increased Venous Pressure Under Development 4 40.36 Quite Low
Nephritis 6 39.76 Quite Low
Renal Disease 2 35.08 Quite Low
Solid Tumor 2 34.16 Quite Low
Renal Failure 2 21.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that this effect of CD22 is mediated by potentiation of plasma membrane calcium-ATPase and requires SHP-1 [37].
Positive_regulation (requires) of SHP-1 in plasma
1) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.08 Pain Relevance 0
These inhibitory domains are phosphorylated by the non-receptor kinase Lyn upon B cell antigen receptor (BCR) activation by IgM ligation, leading to the activation and recruitment of SHP-1 phosphatase [31,32].
Positive_regulation (activation) of SHP-1 in B cell
2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.38 Pain Relevance 0

General Comments

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