INT194957

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.95
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ASPN) proteinaceous extracellular matrix (ASPN)
Anatomy Link Frequency
knee 1
ASPN (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 181 100.00 Very High Very High Very High
metalloproteinase 3 31.12 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 150 100.00 Very High Very High Very High
Knee Osteoarthritis 31 99.56 Very High Very High Very High
Dermal Scarring 48 99.20 Very High Very High Very High
Disease 30 94.64 High High
Osteoarthritis 3 94.20 High High
Injury 3 21.84 Low Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Keloid Scars 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of ASPN with knee OA is found globally, but the effect of ASPN exhibits considerable ethnic differences [19].
ASPN Binding (association) of in knee associated with osteoarthritis
1) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.50 Pain Relevance 0.25
ASPN has been shown to directly bind to transforming growth factor (TGF)-?
ASPN Binding (bind) of
2) Confidence 0.26 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.81 Pain Relevance 0.05
We also pooled data from TKR and THR patients as both patient groups were associated with ASPN in the Japanese population, but even for this larger group there was no difference with the controls (P = 0.8).
ASPN Binding (associated) of
3) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526645 Disease Relevance 0.62 Pain Relevance 0.31
Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians

A recent genetic association study has identified a microsatellite in the coding sequence of the asporin gene as a susceptibility factor for osteoarthritis (OA).

asporin gene Neg (Lack) Binding (association) of associated with osteoarthritis
4) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526645 Disease Relevance 0.79 Pain Relevance 0.37
Even with this later comparison that gave the largest difference in the Japanese population, we did not find evidence of association of OA with the ASPN microsatellite in our patients.
ASPN Binding (association) of associated with osteoarthritis
5) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526645 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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