INT19496

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Context Info
Confidence 0.55
First Reported 1989
Last Reported 1991
Negated 1
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.33
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pomc, Ins1) extracellular region (Pomc, Ins1) cytoplasm (Pomc, Ins1)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
pancreatic islets 2
Pomc (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
opiate 5 98.40 Very High Very High Very High
Opioid 4 98.00 Very High Very High Very High
narcan 5 92.08 High High
antagonist 2 91.72 High High
agonist 4 83.52 Quite High
Disease Link Frequency Relevance Heat
Obesity 5 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carbachol-induced insulin secretion was not affected by beta-endorphin at the lower dose levels but augmented by the peptide at 64 nmol/kg (p less than 0.01).
beta-endorphin Neg (not) Regulation (affected) of Localization (secretion) of insulin
1) Confidence 0.55 Published 1989 Journal Int. J. Pancreatol. Section Abstract Doc Link 2574736 Disease Relevance 0 Pain Relevance 0.94
Since opioid peptides and opiate receptors have been demonstrated in the pancreatic islets, we investigated the effects of beta-endorphin, met-enkephalin, and dynorphin A, on basal and stimulated insulin secretion in the mouse.
beta-endorphin Spec (investigated) Regulation (effects) of Localization (secretion) of insulin in pancreatic islets associated with dynorphin, enkephalin, opiate and opioid
2) Confidence 0.40 Published 1989 Journal Int. J. Pancreatol. Section Abstract Doc Link 2574736 Disease Relevance 0 Pain Relevance 0.75
The results indicate that 1) ob/ob mice display a greater magnitude of response in vivo to beta-endorphin's actions on insulin release compared with lean mice, 2) high concentrations of beta-endorphin exacerbate glucose disposal in ob/ob mice. 3) the prevailing glucose concentration is an important determinant of whether beta-endorphin's effects on insulin release will be stimulatory or inhibitory and 4) these actions are mediated via opiate receptors.
beta-endorphin Spec (whether) Regulation (effects) of Localization (release) of insulin associated with obesity and opiate
3) Confidence 0.16 Published 1991 Journal Peptides Section Abstract Doc Link 2067974 Disease Relevance 0.33 Pain Relevance 0.14

General Comments

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