INT194971

Context Info Confidence 0.14 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.81 Pain Relevance 0.13

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Alox5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 22 79.04 Bioavailability 4 66.12 ischemia 21 5.00 Inflammatory mediators 4 5.00 Inflammatory response 3 5.00 cytokine 2 5.00 ketamine 1 5.00 cINOD 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 2 97.32 Stroke 17 96.00 INFLAMMATION 30 79.04 Injury 22 75.24 Brain Hemorrhage 8 55.84 Aneurism 1 34.68 Cv Unclassified Under Development 13 5.00 Infarction 8 5.00 Middle Cerebral Artery Infarction 7 5.00 Death 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study demonstrates the protective effect of 5-LOX inhibitors when administered either prior to ischemic insult or at reperfusion in a rat model of experimental stroke.

Negative_regulation (effect) of Negative_regulation (inhibitors) of 5-LOX associated with stroke

1) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.81 Pain Relevance 0.13

General Comments

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