INT194975

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Alox5, Nos2) cytosol (Alox5, Nos2) nucleus (Alox5, Nos2)
nuclear envelope (Alox5) aging (Nos2) peroxisome (Nos2)
Alox5 (Rattus norvegicus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 44 70.68 Quite High
cytokine 4 62.96 Quite High
Inflammatory response 6 24.92 Low Low
ischemia 42 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 12 83.92 Quite High
INFLAMMATION 60 70.68 Quite High
Disease 6 67.00 Quite High
Injury 44 57.72 Quite High
Stroke 34 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 26 5.00 Very Low Very Low Very Low
Infarction 16 5.00 Very Low Very Low Very Low
Brain Hemorrhage 16 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 14 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that 5-LOX inhibition lead to the down-regulation of iNOS expression.


Negative_regulation (inhibition) of 5-LOX Negative_regulation (down) of Gene_expression (expression) of iNOS
1) Confidence 0.13 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.35 Pain Relevance 0.07
These data suggest that 5-LOX inhibition lead to the down-regulation of iNOS expression.


Negative_regulation (inhibition) of 5-LOX Negative_regulation (regulation) of Gene_expression (expression) of iNOS
2) Confidence 0.13 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

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