INT194990

Context Info Confidence 0.23 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.66 Pain Relevance 0

cytosol (FHIT) plasma membrane (FHIT) nucleus (FHIT) cytoplasm (FHIT)

FHIT (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 6 5.00 cytokine 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Chondrosarcoma 37 99.52 Sarcoma 4 96.96 Aneuploidy 1 90.80 Aggression 1 78.00 Leukocytosis 30 74.92 Cancer 20 74.72 Lung Cancer 3 71.28 Metastasis 6 59.96 Malignant Fibrous Histiocytoma 8 27.04 Liposarcoma 3 19.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Gene alterations in p53, Rb and FHIT are reported to be responsible for the "switch" to a high-grade anaplastic sarcoma (dedifferentiated components) from monoclonal origin of demonstrated dedifferentiated chondrosaroma [24].

Regulation (alterations) of FHIT associated with sarcoma

1) Confidence 0.23 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.66 Pain Relevance 0

General Comments

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