INT194993

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.96
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
eye 1
adipocytes 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 84.24 Quite High
Inflammation 24 83.88 Quite High
withdrawal 6 83.36 Quite High
agonist 30 81.64 Quite High
Pain 8 62.00 Quite High
Inflammatory response 2 53.68 Quite High
qutenza 130 50.00 Quite Low
antagonist 11 25.96 Quite Low
Dismenorea 1 19.52 Low Low
Inflammatory mediators 1 7.52 Low Low
Disease Link Frequency Relevance Heat
Retinoblastoma 80 100.00 Very High Very High Very High
Lipoma 44 99.52 Very High Very High Very High
Chondrosarcoma 37 99.52 Very High Very High Very High
Disorders Of The Lacrimal System 176 99.44 Very High Very High Very High
Chromosome Aberrations 3 99.00 Very High Very High Very High
Cancer 289 98.44 Very High Very High Very High
Malignant Neoplastic Disease 46 97.68 Very High Very High Very High
Papillomavirus Infection 1 97.24 Very High Very High Very High
Sarcoma 11 96.60 Very High Very High Very High
Eyelid Disease 4 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural alterations of RB1 seem to be involved in the pathogenesis of the secondary malignancy after treatment of retinoblastoma.


RB1 Binding (alterations) of associated with malignant neoplastic disease and retinoblastoma
1) Confidence 0.37 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615012 Disease Relevance 1.21 Pain Relevance 0
The leading genetic theory for lipoma formation proposes that spontaneous karyotypic anomalies lead to chromosomal fusion products which promote proliferation of adipocytes.5 Although numerous other chromosomal aberrations have been described, lipomas are most commonly associated with translocations and rearrangements of the 12q13˜q15 chromosomal region.5,14 However, not all lipomatous neoplasms exhibit abnormal karyotypes.15 As an example, lipomas have been described in association with retinoblastoma gene mutations.16
retinoblastoma Binding (association) of in adipocytes associated with chromosome aberrations, lipoma, cancer, obesity and retinoblastoma
2) Confidence 0.36 Published 2010 Journal Eplasty Section Body Doc Link PMC2964102 Disease Relevance 1.72 Pain Relevance 0.06
PRB binds and inhibits NF-?
PRB Binding (binds) of
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.71 Pain Relevance 0.18
OGF treatment does not change total Rb protein but decreases the amount of phosphorylated Rb
Rb Binding (amount) of associated with retinoblastoma
4) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.70 Pain Relevance 0
OGF treatment does not change total Rb protein but decreases the amount of phosphorylated Rb
Rb Neg (not) Binding (protein) of associated with retinoblastoma
5) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.68 Pain Relevance 0
Several questions, however, remain unanswered: (1) what binds RB?
RB Binding (binds) of
6) Confidence 0.27 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698717 Disease Relevance 0.70 Pain Relevance 0
However, the association between RB staining and dry eye has not yet been fully characterized, as RB staining can also be observed in asymptomatic patients (Schein et al 1997; Khan-Lim 2004) and seems to lack a clearly defined relationship with subjective symptoms (Schein et al 1997; Lin et al 2005).
RB Binding (association) of in eye associated with disorders of the lacrimal system
7) Confidence 0.21 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698717 Disease Relevance 0.45 Pain Relevance 0
Gene alterations in p53, Rb and FHIT are reported to be responsible for the "switch" to a high-grade anaplastic sarcoma (dedifferentiated components) from monoclonal origin of demonstrated dedifferentiated chondrosaroma [24].
Rb Binding (alterations) of associated with sarcoma
8) Confidence 0.20 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.61 Pain Relevance 0
When

hyperphosphorylated, pRB cannot bind to E2F transcription factors that can

pRB Binding (bind) of
9) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.10 Pain Relevance 0
p16 specifically inhibits the cyclin D1-CDK4/6 complex and, along with the main substrate, forms the retinoblastoma gene product (pRb), which is the most important regulatory pathway involved in the G1/S transition [45,46].
pRb Binding (forms) of associated with retinoblastoma
10) Confidence 0.15 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.85 Pain Relevance 0
increasing the amount of hypophosphorylated pRb able to bind E2F.
pRb Binding (bind) of
11) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.53 Pain Relevance 0.04
RBBP6 has been shown to bind p53, inhibit adenoviral E1A from binding pRb, and may have a ubiquitin-like domain [72].
pRb Binding (binding) of
12) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.50 Pain Relevance 0
The Rb family proteins bind to a moiety within the transcriptional activation region of E2Fs, effectively repressing their activity.
Rb Binding (bind) of
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0 Pain Relevance 0
activation induced by PGJ2 is modulated through an interaction with the retinoblastoma protein (Rb) and histone deacetylase [106].
Rb Binding (interaction) of associated with retinoblastoma
14) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 1.10 Pain Relevance 0.11
Inactivated retinoblastoma (p-Rb) protein regulates the progression from G1 to S phase through its association with the E2F family of transcription factors [45], [46].
p-Rb Binding (association) of associated with retinoblastoma
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.10 Pain Relevance 0

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