INT1950

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Context Info
Confidence 0.49
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 40
Disease Relevance 20.17
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 6
microglia 4
lung 4
peritoneum 2
brain 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 795 100.00 Very High Very High Very High
cytokine 495 100.00 Very High Very High Very High
metalloproteinase 30 99.64 Very High Very High Very High
adenocard 73 99.56 Very High Very High Very High
Inflammatory response 144 97.24 Very High Very High Very High
Inflammatory mediators 60 96.80 Very High Very High Very High
cINOD 38 95.44 Very High Very High Very High
agonist 38 94.40 High High
chemokine 42 92.36 High High
monoamine 2 90.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 991 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 31 99.96 Very High Very High Very High
Pulmonary Disease 326 99.84 Very High Very High Very High
Peritonitis 49 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 25 99.32 Very High Very High Very High
Toxicity 14 99.08 Very High Very High Very High
Nicotine Addiction 84 99.00 Very High Very High Very High
Injury 128 98.68 Very High Very High Very High
Rupture 6 98.32 Very High Very High Very High
Infection 111 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of TLR4 induces production of the pro-inflammatory cytokines TNF, IL-1?
Positive_regulation (induces) of Positive_regulation (Activation) of TLR4 associated with inflammation and cytokine
1) Confidence 0.49 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.82 Pain Relevance 0.30
An experimental model has shown that activated macrophages within plaques are capable of degrading the extracellular matrix by secretion of MMP 9 (matrix metalloproteinase 9), which can be stimulated by TLR4 activation and which induces plaque degradation and rupture [24,25].
Positive_regulation (stimulated) of Positive_regulation (activation) of TLR4 in macrophages associated with rupture and metalloproteinase
2) Confidence 0.48 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.68 Pain Relevance 0.23
It is concluded that the drug induced inhibition of LPS activation was due solely to the toxicity of the compounds.
Positive_regulation (induced) of Positive_regulation (activation) of LPS associated with toxicity
3) Confidence 0.44 Published 1978 Journal Scand. J. Immunol. Section Abstract Doc Link 306664 Disease Relevance 0.17 Pain Relevance 0.08
This gene encodes a receptor required for activation of TLR4 by endotoxin.
Positive_regulation (required) of Positive_regulation (activation) of TLR4
4) Confidence 0.39 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 0.35 Pain Relevance 0
Interestingly, LPS stimulation increased the sTLR4 mRNA expression, suggesting a negative feedback to inhibit excessive cytokine production.
Positive_regulation (increased) of Positive_regulation (stimulation) of LPS associated with cytokine
5) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.42 Pain Relevance 0.16
Although LPS stimulation seemed to increase the mRNA for IL-6, CXCL-1 and CSF-2; the mRNA levels for these 3 genes were not significantly different from the untreated cells (Table 1).


Positive_regulation (increase) of Positive_regulation (stimulation) of LPS
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.07 Pain Relevance 0.23
All of these receptors require the adaptor protein MyD88 for immediate response to LPS and initiate a bifurcated signal transduction cascade that culminates in altered gene transcription, primarily via NF-?
Positive_regulation (require) of Positive_regulation (response) of LPS
7) Confidence 0.35 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.18 Pain Relevance 0.12
All of these receptors require the adaptor protein MyD88 for immediate response to LPS and initiate a bifurcated signal transduction cascade that culminates in altered gene transcription, primarily via NF-?
Positive_regulation (immediate) of Positive_regulation (response) of LPS
8) Confidence 0.35 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.17 Pain Relevance 0.12
All of these receptors require the adaptor protein MyD88 for immediate response to LPS and initiate a bifurcated signal transduction cascade that culminates in altered gene transcription, primarily via NF-?
Positive_regulation (culminates) of Positive_regulation (response) of LPS
9) Confidence 0.35 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.18 Pain Relevance 0.13
Activation of TLR-4 induces a multitude of pro-inflammatory cytokines via activation of transcription factors, nuclear factor (NF)?
Positive_regulation (induces) of Positive_regulation (Activation) of TLR-4 associated with inflammation and cytokine
10) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.00 Pain Relevance 0.49
HA dependent TLR4 activation involves CD44 in addition to MD-2 [88].
Positive_regulation (dependent) of Positive_regulation (activation) of TLR4
11) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.09 Pain Relevance 0.03
In the present study, we found that pre-induction of HO-1 attenuate LPS-induced expression of COX-2 protein and therefore decreased PGE2 accumulation.
Positive_regulation (induced) of Positive_regulation (induction) of LPS
12) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.65 Pain Relevance 0.17
The innate immunity is rapidly triggered after LPS, primarily via activation of toll-like receptor 4 (TLR-4) [17].
Positive_regulation (triggered) of Positive_regulation (activation) of TLR-4
13) Confidence 0.28 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.07 Pain Relevance 0.49
LPS injection (100 µg/mice, i.p.) induced an elevation of IL-10 levels in CV, LPS-GF and GF mice with similar courses: the levels peaked at 1.5 to 3 h, then returned to normal levels at 6 h (Fig. 1).
Positive_regulation (induced) of Positive_regulation (elevation) of LPS
14) Confidence 0.28 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.09 Pain Relevance 0.09
Stimulation of cells with increasing concentrations of LPS (0–10 ?
Positive_regulation (increasing) of Positive_regulation (increasing) of LPS
15) Confidence 0.27 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0 Pain Relevance 0.18
Stimulation of cells with increasing concentrations of LPS (0–10 ?
Positive_regulation (Stimulation) of Positive_regulation (increasing) of LPS
16) Confidence 0.27 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0 Pain Relevance 0.18
Cells were stimulated with increasing concentrations of LPS (0–10 ?
Positive_regulation (increasing) of Positive_regulation (concentrations) of LPS
17) Confidence 0.27 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.29 Pain Relevance 0.16
Cells were stimulated with increasing concentrations of LPS (0–10 ?
Positive_regulation (stimulated) of Positive_regulation (concentrations) of LPS
18) Confidence 0.27 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.29 Pain Relevance 0.16
mRNA occurred upon LPS stimulation compared to HMGB1 [20, 104, 105].
Positive_regulation (occurred) of Positive_regulation (stimulation) of LPS
19) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.46 Pain Relevance 0.31
The required concentration of LPS to induce significant COX-2 protein expression in bEnd.3 cells was a concentration of 100 ?
Positive_regulation (required) of Positive_regulation (concentration) of LPS
20) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.76 Pain Relevance 0.15

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