INT19501

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.06
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MYCN) DNA binding (MYCN)
Anatomy Link Frequency
TEK 1
MYCN (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
Opioid 3 98.72 Very High Very High Very High
antagonist 7 95.64 Very High Very High Very High
opiate 1 89.04 High High
chemokine 3 77.12 Quite High
cytokine 1 67.00 Quite High
Inflammation 4 66.60 Quite High
agonist 9 65.28 Quite High
COX2 2 49.92 Quite Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.84 Very High Very High Very High
Cancer 197 98.00 Very High Very High Very High
Adhesions 3 97.12 Very High Very High Very High
Reprotox - General 1 1 89.60 High High
Retinoblastoma 4 82.56 Quite High
Leukemia 5 81.96 Quite High
Colon Cancer 5 81.76 Quite High
Teratocarcinoma 3 77.52 Quite High
Necrosis 5 70.72 Quite High
INFLAMMATION 5 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since both POMC and MYCN genes are present on the same chromosome segment (2p23), it is possible that the 2 genes are coamplified and coexpressed.
Gene_expression (present) of MYCN
1) Confidence 0.75 Published 1991 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2068137 Disease Relevance 0.16 Pain Relevance 0.09
mechanism. 15-d PG J2 inhibits N-myc expression in neuroblastoma cells [134] while it does not
Gene_expression (expression) of N-myc associated with neuroblastoma
2) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.42 Pain Relevance 0.11
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of N-MYC in TEK associated with metalloproteinase
3) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.96 Pain Relevance 0.05
N-MYC N-MYC proto-oncogene
Gene_expression (proto) of N-MYC
4) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.76 Pain Relevance 0.40
N-MYC N-MYC proto-oncogene
Gene_expression (proto) of N-MYC
5) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.76 Pain Relevance 0.40

General Comments

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