INT195058

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.56
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ALPL) plasma membrane (ALPL)
Anatomy Link Frequency
osteoblasts 2
ALPL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 26 84.24 Quite High
headache 3 75.28 Quite High
antagonist 7 72.00 Quite High
withdrawal 3 65.76 Quite High
Inflammation 6 56.64 Quite High
Analgesic 2 35.84 Quite Low
Pain 20 5.00 Very Low Very Low Very Low
cva 15 5.00 Very Low Very Low Very Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 81 99.68 Very High Very High Very High
Disease Progression 6 99.52 Very High Very High Very High
Phosphate Metabolism Disorders 55 98.64 Very High Very High Very High
Prostate Cancer 111 82.60 Quite High
Hypercalcemia 22 78.88 Quite High
Pressure And Volume Under Development 1 76.56 Quite High
Rhinitis 1 75.68 Quite High
Headache 3 75.28 Quite High
Hip Fractures 10 73.92 Quite High
Postmenopausal Osteoporosis 13 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, it is important to analyze this particular effect in more detail in the future, because induction of TNSALP gene expression might be a therapeutic target in HP.
Positive_regulation (induction) of Gene_expression (expression) of TNSALP associated with phosphate metabolism disorders
1) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.16 Pain Relevance 0.28
There was improvement in bone alkaline phosphatase (?
Positive_regulation (improvement) of Gene_expression (improvement) of bone alkaline phosphatase
2) Confidence 0.04 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.75 Pain Relevance 0.14
A recent study has shown that strontium ranelate increases the expression of the bone-specific alkaline phosphatase (bALP; osteoblast differentiation) and the number of the bone nodules (osteoblast activity) of murine osteoblasts.
Positive_regulation (increases) of Gene_expression (expression) of bone-specific alkaline phosphatase in osteoblasts associated with osteoporosis
3) Confidence 0.02 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.65 Pain Relevance 0

General Comments

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