INT195080

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 18
Disease Relevance 26.67
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnc) extracellular space (Tnc) extracellular region (Tnc)
cell adhesion (Tnc) proteinaceous extracellular matrix (Tnc)
Anatomy Link Frequency
eye 1
keratinocyte 1
T lymphocytes 1
Tnc (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 75 99.64 Very High Very High Very High
corticosteroid 90 99.54 Very High Very High Very High
Lamotrigine 90 99.44 Very High Very High Very High
Glutamate 23 99.20 Very High Very High Very High
carbamazepine 180 98.82 Very High Very High Very High
Paracetamol 30 92.64 High High
withdrawal 45 81.08 Quite High
cytokine 54 71.76 Quite High
antiepileptic Drug 45 68.92 Quite High
Inflammation 40 53.12 Quite High
Disease Link Frequency Relevance Heat
Staphylococcus Infection 1920 100.00 Very High Very High Very High
Bullous Skin Disease 1590 100.00 Very High Very High Very High
Death 146 100.00 Very High Very High Very High
Injury 117 99.64 Very High Very High Very High
Infection 31 99.48 Very High Very High Very High
Blister 165 99.44 Very High Very High Very High
Bacterial Respiratory Disease 30 99.20 Very High Very High Very High
Apoptosis 151 98.60 Very High Very High Very High
Cold Sores 15 98.16 Very High Very High Very High
Disease 314 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the induction of chondroitin sulfate proteoglycans, tenascin, S-100B as well as glutamate transporter proteins, GLAST and GLT-1, and glutamine synthetase are independent of IL-1RI signaling.
Positive_regulation (induction) of tenascin associated with glutamate
1) Confidence 0.45 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1533808 Disease Relevance 0.71 Pain Relevance 0.09
Immunohistochemistry was performed for PTPRG, TNFRSF1A, and TNC, all of which showed positive IHC staining in human pancreatic cancer (Figure 3).
Positive_regulation (performed) of TNC associated with pancreatic cancer
2) Confidence 0.17 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.82 Pain Relevance 0
This RegiSCAR study revealed that HLA-B*1502 is neither a marker for carbamazepine, sulfamethoxazole, lamotrigine, or NSAID's of oxicam-type induced SJS/TEN nor a sufficient explanation for the cause of the disease in Europeans [35,36].
Neg (nor) Positive_regulation (induced) of TEN associated with staphylococcus infection, cinod, lamotrigine, disease, bullous skin disease and carbamazepine
3) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 0.99 Pain Relevance 0.64
Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type.
Positive_regulation (inducing) of TEN associated with staphylococcus infection, cinod, bullous skin disease and carbamazepine
4) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 1.92 Pain Relevance 0.17
In order to identify the culprit drug(s) it is important to consider the chronology of administration of the drug and the reported ability of the drug to induce SJS/TEN.
Positive_regulation (induce) of TEN associated with staphylococcus infection and bullous skin disease
5) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.43 Pain Relevance 0.11
This study identified nevirapine, lamotrigine, and sertraline, as drugs with a significantly increased risk of inducing SJS/TEN.
Positive_regulation (inducing) of TEN associated with staphylococcus infection, lamotrigine and bullous skin disease
6) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.13 Pain Relevance 0.30
Induction of SJS/TEN has, however, been documented following local eye treatment [104,105].
Positive_regulation (Induction) of TEN in eye associated with staphylococcus infection and bullous skin disease
7) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.19 Pain Relevance 0
An often addressed issue is the induction of TEN or SJS after vaccination.
Positive_regulation (induction) of TEN associated with staphylococcus infection and bullous skin disease
8) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.56 Pain Relevance 0.30
In a case control study of patients hospitalized for SJS/TEN in selected hospitals in France, Germany, Italy and Portugal between 1989 and 1993, Roujeau et al. reported that the following drugs are at increased risk of inducing SJS/TEN when used over a short period of time: trimetroprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones and chlormezanone.
Positive_regulation (inducing) of TEN associated with staphylococcus infection and bullous skin disease
9) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.61 Pain Relevance 0.08
Indeed, in the early phase of disease, blister fluid contains mainly cytotoxic CD8+T lymphocytes [40,41], suggesting that a major histocompatibility (MHC) class-I restricted drug presentation leads to clonal expansion of CD8+ CTLs, and the subsequent - to date only incompletely understood - immune reaction that causes SJS/TEN.
Positive_regulation (causes) of TEN in T lymphocytes associated with staphylococcus infection, blister, bullous skin disease and disease
10) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.13 Pain Relevance 0.03
Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown.
Positive_regulation (cause) of TEN associated with staphylococcus infection, cold sores, bacterial respiratory disease and bullous skin disease
11) Confidence 0.07 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 1.84 Pain Relevance 0.13
Among drugs usually taken for longer periods of time (carbamazepine, phenytoin, phenobarbital, valproic acid, non-steroidal antinflammatory drugs of the oxicam-type, allopurinol and corticosteroids), the highest risk of induction of SJS/TEN occurs during the first 2 months of treatment with a sharp drop of incidence thereafter [8].
Positive_regulation (induction) of TEN associated with staphylococcus infection, corticosteroid, bullous skin disease and carbamazepine
12) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.31 Pain Relevance 0.13
Older drugs identified as having a high risk of inducing SJS/TEN were sulfamethoxazol/trimethoprim (SMX/TMP), sulfonamides (sulfasalazine, sulfadiazine, sulfadoxine, sulfafurazole), allopurinol, carbamazepine, phenytoin, phenobarbital, and NSAID's of the oxicam-type (meloxicam, piroxicam, tenoxicam).
Positive_regulation (inducing) of TEN associated with staphylococcus infection, cinod, bullous skin disease and carbamazepine
13) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.10 Pain Relevance 0.35
It was only as more patients with TEN were reported in the years following Lyell's original publication, that it became clear that TEN was drug induced, and that certain drugs such as sulfonamides, pyrazolones, barbiturates, and antiepileptics were the most frequent triggers of TEN.
Positive_regulation (triggers) of TEN associated with staphylococcus infection
14) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.12 Pain Relevance 0
In principle, the severity of SJS and TEN does not allow re-challenge and intradermal testing with the culprit drugs due to the feared risk of re-inducing a second episode of SJS/TEN, although two case reports describe intradermal testing without triggering of a second episode of TEN [102,103].
Neg (not) Positive_regulation (inducing) of TEN associated with staphylococcus infection and bullous skin disease
15) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.25 Pain Relevance 0.03
Gene expression analysis of blister fluid cells, and analysis of blister fluid from patients with SJS/TEN has also recently identified secretory granulysin (a cationic cytolytic protein secreted by CTL's, NK cells and NKT cells) as a key molecule responsible for the induction of keratinocyte death in TEN [43].
Positive_regulation (induction) of TEN in keratinocyte associated with staphylococcus infection, blister, bullous skin disease and death
16) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.87 Pain Relevance 0
Mycoplasma pneumoniae infections are widely documented to cause SJS and TEN without initial exposure to drugs [13-15].
Positive_regulation (cause) of TEN associated with staphylococcus infection, bacterial respiratory disease, bullous skin disease and infection
17) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.39 Pain Relevance 0
Ten death-related genes upregulated by both injuries were used for array validation by means of qRT–PCR.
Positive_regulation (upregulated) of Ten associated with injury and death
18) Confidence 0.01 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2426719 Disease Relevance 1.29 Pain Relevance 0

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