INT195085

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 12.26
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
brain 4
astrocytes 1
molar 1
microglia 1
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 92 100.00 Very High Very High Very High
fluoxetine 18 99.84 Very High Very High Very High
ischemia 12 97.88 Very High Very High Very High
Neuritis 3 94.76 High High
cva 12 93.16 High High
endometriosis 4 82.04 Quite High
Pain 5 80.96 Quite High
cytokine 107 78.12 Quite High
diabetic neuropathy 4 76.72 Quite High
sSRI 96 75.60 Quite High
Disease Link Frequency Relevance Heat
Injury 290 99.74 Very High Very High Very High
Brain Injury 134 99.64 Very High Very High Very High
Stab Wounds 60 99.60 Very High Very High Very High
Apoptosis 193 99.20 Very High Very High Very High
Syndrome 13 98.28 Very High Very High Very High
Disease 221 98.04 Very High Very High Very High
Cerebral Malaria 26 98.04 Very High Very High Very High
Cv Unclassified Under Development 9 97.88 Very High Very High Very High
Infarction 4 97.52 Very High Very High Very High
Alzheimer's Dementia 40 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100B is expressed primarily in the astrocytes of the human cortex and melanocytes as well as myeloid dendritic cells [42].
Gene_expression (expressed) of S100B in astrocytes
1) Confidence 0.56 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.77 Pain Relevance 0.08
Elevated levels of S100B have been found in patients following brain trauma, ischemia/infarction, Alzheimer's disease, and Down's syndrome [42].
Gene_expression (levels) of S100B in brain associated with syndrome, ischemia, disease, infarction and brain injury
2) Confidence 0.49 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.93 Pain Relevance 0.08
1, S100B, and NF-L mRNA expressions at 8 wpi (Figs. 5A, 6A)?
Gene_expression (expressions) of S100B
3) Confidence 0.46 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.74 Pain Relevance 0.03
Similarly, it was suggested that elevated S100B levels are involved in the development of Down's syndrome and AD [61]; its expression was also correlated with the density of dystrophic neuritis with overexpressed A?
Gene_expression (levels) of S100B associated with syndrome, disease and neuritis
4) Confidence 0.46 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.76 Pain Relevance 0.09
expression in microglia by S100B requires the concurrent activation of NF-?
Gene_expression (expression) of S100B in microglia
5) Confidence 0.43 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0
While the interaction of RAGE with S100B can produce anti-apoptotic signals, micro-molar concentrations of S100B will produce oxyradicals, inducing apoptosis.
Gene_expression (produce) of S100B in molar associated with apoptosis
6) Confidence 0.43 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.21
1, S100B, and NF-L mRNA expressions at 8 wpi (Figs. 5A, 6A)?
Gene_expression (expressions) of S100B
7) Confidence 0.40 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.74 Pain Relevance 0.03
The older mice had higher levels of S100B.
Gene_expression (levels) of S100B
8) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.11 Pain Relevance 0.92
Our results show that in both WT and receptor-null mice, stab wound injury increased GLAST, GLT-1, GS and S-100B protein expression at 3 day post injury by 8, 6, 4 and 12 fold, respectively (Fig. 7).
Gene_expression (expression) of S-100B protein associated with injury and stab wounds
9) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.44 Pain Relevance 0.28
Thus, a neocortical stab wound injury induces the expression of GLT-1, GLAST, the GS, and S-100B, but our data indicate that this induction is independent of IL-1R1.
Gene_expression (expression) of S-100B associated with injury and stab wounds
10) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.15
To assess the functional state of astrocytes after traumatic brain injury, we analyzed the expression of two glutamate transporters, glutamate aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1/EAAT2), the glutamate transaminase, glutamine synthetase (GS) and the calcium regulatory protein S-100B.
Spec (analyzed) Gene_expression (expression) of protein S-100B in brain associated with glutamate and brain injury
11) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.25
As astrocytes also buffer levels of brain calcium and as the calcium binding protein S-100B also has neurotrophic properties [38-40], we measured the levels of S-100B after injury.
Gene_expression (levels) of S-100B in brain associated with injury
12) Confidence 0.08 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.82 Pain Relevance 0.16
Axons are the most susceptible to ischemic or toxic damage in different brain areas, and axonal injury detected by elevated CSF levels of tau protein and S-100B (markers of axonal damage) were observed during cerebral malaria in Kenyan children [25].
Gene_expression (levels) of S-100B in brain associated with injury and cerebral malaria
13) Confidence 0.01 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.82 Pain Relevance 0.05

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