INT195089

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a2) plasma membrane (Slc1a2)
Anatomy Link Frequency
whisker 1
cortex 1
Slc1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 92 100.00 Very High Very High Very High
Somatosensory cortex 3 94.44 High High
excitatory amino acid 1 94.32 High High
cytokine 18 71.76 Quite High
anesthesia 4 37.28 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 111 98.96 Very High Very High Very High
Stab Wounds 30 93.52 High High
Penetrating Head Injuries 10 93.44 High High
Gliosis 4 92.56 High High
Brain Injury 20 76.72 Quite High
Death 6 72.32 Quite High
Epilepsy 2 72.32 Quite High
Hypoxia 2 70.88 Quite High
Cicatrix 12 62.72 Quite High
Disease 8 8.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blot analysis on single barrel columns corresponding to the stimulated whisker, we found that expression levels of GLT1 and GLAST were significantly increased.
Positive_regulation (increased) of GLT1 in whisker
1) Confidence 0.66 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.15 Pain Relevance 0.28
For instance, GLT-1 levels increase 2.5 fold above the control three days after the trauma caused by transplanting E18 neocortical tissue into rat cortex [76].
Positive_regulation (increase) of GLT-1 in cortex associated with injury
2) Confidence 0.42 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.69 Pain Relevance 0.25
However, the induction of chondroitin sulfate proteoglycans, tenascin, S-100B as well as glutamate transporter proteins, GLAST and GLT-1, and glutamine synthetase are independent of IL-1RI signaling.
Positive_regulation (induction) of GLT-1 associated with glutamate
3) Confidence 0.33 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1533808 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

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