INT19509

Context Info Confidence 0.78 First Reported 1988 Last Reported 2011 Negated 1 Speculated 0 Reported most in Abstract Documents 55 Total Number 55 Disease Relevance 28.25 Pain Relevance 18.67

extracellular space (Ifng) extracellular region (Ifng)

Anatomy Link Frequency T cell 8 thymocytes 5 spleen 4 lymphocyte 2 plaque 2 Ifng (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 152 100.00 substance P 13 100.00 Sciatic nerve 6 99.60 Inflammation 239 99.52 Demyelination 9 99.12 acular 8 99.10 chemokine 45 99.08 cocaine 41 98.98 Opioid 13 98.72 Morphine 29 98.28

Disease Link Frequency Relevance Heat Cancer 105 100.00 Necrosis 21 100.00 INFLAMMATION 263 99.52 Congenital Anomalies 11 99.42 Demyelinating Disease 21 99.12 Infection 84 98.60 Colitis 6 98.56 Multiple Sclerosis 227 98.26 Malaria 51 98.16 Multiple Myeloma 36 98.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-18 is a proinflammatory cytokine of the IL-1 family, recognized for its ability to promote IFN-gamma secretion.

Localization (secretion) of IFN-gamma associated with cytokine

1) Confidence 0.78 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 0.88 Pain Relevance 0.58

Sera from 3 renal allograft recipients treated with OKT3 were studied and showed that a massive although transient release of some cytokines namely, Tumor Necrosis Factor alpha, Interleukin 2 and Interferon gamma is observed following the first OKT3 injection.

Localization (release) of Interferon gamma associated with necrosis, cancer and cytokine

2) Confidence 0.78 Published 1988 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 3146414 Disease Relevance 0.76 Pain Relevance 0.14

The spleens of mice treated with PDT + IT-DC contained tumor-specific cytotoxic and IFN-gamma-secreting T cells whereas the spleens of control groups did not.

Localization (ecreting ) of IFN-gamma in spleens

3) Confidence 0.78 Published 2006 Journal Clin. Cancer Res. Section Body Doc Link 16638867 Disease Relevance 0.07 Pain Relevance 0

Oncomice thymocytes secreted more IFN-gamma than FVB thymocytes, their secretion was downregulated by in vivo treatment with alcohol, while it was upregulated in FVB thymocytes.

Localization (secreted) of IFN-gamma in thymocytes associated with alcohol

4) Confidence 0.73 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.23 Pain Relevance 0.52

IFN-gamma secretion was lower in Oncomice splenocytes from animals receiving alcohol.

Localization (secretion) of IFN-gamma associated with alcohol

5) Confidence 0.73 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.22 Pain Relevance 0.55

The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice splenocytes and thymocytes depended on the presence of the oncogene product, on the in vivo pretreatment with alcohol, or on the in vitro treatment with cocaine or morphine.

Localization (secretion) of IFN-gamma in thymocytes associated with morphine, cocaine and alcohol

6) Confidence 0.73 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.27 Pain Relevance 0.32

In vitro experiments using isolated splenic NK cells confirmed their ability to respond to IL-18 and SP and to secrete IFN-gamma protein.

Localization (secrete) of IFN-gamma protein in NK cells associated with substance p

7) Confidence 0.69 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.61 Pain Relevance 0.47

Upon ConA stimulation, SM735 suppressed IFN-gamma in a dose-dependent manner, but did not affect IL-2 secretion.

Localization (secretion) of IFN-gamma

8) Confidence 0.68 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 16225758 Disease Relevance 0.05 Pain Relevance 0

When CRT/E7 DNA vaccinated mice treated with ketorolac, the declines of frequencies of E7-specific IFN-gamma-secreting CD8+ T cell precursors were slower in the morphine-treated group.

Localization (secreting) of IFN-gamma in T cell associated with acular and morphine

9) Confidence 0.68 Published 2010 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 20377998 Disease Relevance 0.37 Pain Relevance 1.78

Oncomice thymocytes cultured in the presence of Con A and cocaine showed a diminished release of sIL-2R and a lower secretion of IFN-gamma, a phenomenon not observed in FVB thymocytes.

Localization (secretion) of IFN-gamma in thymocytes associated with cocaine

10) Confidence 0.68 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.22 Pain Relevance 0.42

The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice spleen and thymus cells depended on the presence of the oncogene product, on the in vivo pretreatment with cocaine, or on the in vitro treatment with cocaine or morphine.

Localization (secretion) of IFN-gamma in thymus associated with morphine and cocaine

11) Confidence 0.68 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.27 Pain Relevance 0.26

IFN-gamma secretion was lower in Oncomice splenocytes.

Localization (secretion) of IFN-gamma

12) Confidence 0.68 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.22 Pain Relevance 0.42

Oncomice thymocytes secreted more IFN-gamma than FVB thymocytes.

Localization (secreted) of IFN-gamma in thymocytes

13) Confidence 0.68 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.24 Pain Relevance 0.40

Only 10 mM U-50488 led to a decrease in nitrite release from interferon-gamma and LPS-stimulated macrophages.

Localization (release) of interferon-gamma in macrophages

14) Confidence 0.65 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189065 Disease Relevance 0 Pain Relevance 1.03

Moreover, immunoneutralization of IFN-gamma may be therapeutically effective for developing APAP-induced liver injury.

Localization (immunoneutralization) of IFN-gamma in liver associated with injury

15) Confidence 0.64 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 1.03 Pain Relevance 0.21

The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice splenocytes and thymocytes depended on the presence of the oncogene product, on the in vivo pretreatment with alcohol, or on the in vitro treatment with cocaine or morphine.

Localization (release) of IFN-gamma in thymocytes associated with morphine, cocaine and alcohol

16) Confidence 0.64 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.26 Pain Relevance 0.32

In these IL-12-/- mice the onset of clinical disease was delayed, and the incidence and severity of EAN were significantly reduced compared to that in wild-type mice.The former group's clinical manifestations were associated with less P0-peptide 180-199 induced secretion of interferon-gamma (IFN-gamma) by splenocytes in vitro and low production of anti-P0-peptide 180-199 IgG2b antibodies in serum.

Localization (ecretion ) of interferon-gamma associated with disease and neuritis

17) Confidence 0.57 Published 2002 Journal Brain Pathol. Section Abstract Doc Link 12408228 Disease Relevance 0.96 Pain Relevance 0.69

In these IL-12-/- mice the onset of clinical disease was delayed, and the incidence and severity of EAN were significantly reduced compared to that in wild-type mice.The former group's clinical manifestations were associated with less P0-peptide 180-199 induced secretion of interferon-gamma (IFN-gamma) by splenocytes in vitro and low production of anti-P0-peptide 180-199 IgG2b antibodies in serum.

Localization (ecretion ) of IFN-gamma associated with disease and neuritis

18) Confidence 0.57 Published 2002 Journal Brain Pathol. Section Abstract Doc Link 12408228 Disease Relevance 0.96 Pain Relevance 0.69

However, numbers of IFN-gamma-secreting cells from the spleen were significantly augmented in the IFN-gammaR(-/-) mice, reflecting a failure of negative feedback circuits.

Localization (ecreting ) of IFN-gamma in spleen

19) Confidence 0.51 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11358460 Disease Relevance 1.07 Pain Relevance 0.73

Mice given NK-1R antagonist after NSAID induction of severe colitis showed nearly complete reversal of inflammation, and LP T cells ceased IFN-gamma secretion.

Localization (secretion) of IFN-gamma in T cells associated with colitis, inflammation, antagonist and cinod

20) Confidence 0.45 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.82 Pain Relevance 0.84

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