INT195090

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.15
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl2) plasma membrane (F2rl2) signal transducer activity (F2rl2)
F2rl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 23 97.92 Very High Very High Very High
cytokine 10 93.24 High High
Inflammation 7 90.56 High High
cva 1 81.36 Quite High
ischemia 2 76.44 Quite High
Mechanotransduction 4 65.08 Quite High
Inflammatory mediators 3 60.80 Quite High
addiction 2 28.44 Quite Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 63 99.38 Very High Very High Very High
Atherosclerosis 1 98.88 Very High Very High Very High
Injury 56 98.76 Very High Very High Very High
Stress 40 93.76 High High
Hypertrophy 3 90.96 High High
INFLAMMATION 11 90.56 High High
Penetrating Head Injuries 5 87.16 High High
Cv General 3 Under Development 1 81.36 Quite High
Vasculitis 1 77.88 Quite High
Brain Injury 10 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Positive_regulation (induced) of Gene_expression (levels) of protease-activated receptor
1) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.89 Pain Relevance 0.17
At least as attractive, and not mutually exclusive is the hypothesis that arterial injury, like in early atherosclerosis, will up-regulate endothelial expression of proteinase-activated-receptor 2 [53], which will be activated proteolytically within the atherosclerotic lesion and via systemic proteases to specifically sensitize endothelial TRPV4 channels to respond to mechanical stress [34].


Positive_regulation (activated) of Gene_expression (expression) of proteinase-activated-receptor 2 associated with stress, atherosclerosis, injury and increased venous pressure under development
2) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.20 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox