INT195091

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
brain 2
extracellular matrix 2
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 46 96.72 Very High Very High Very High
cva 2 84.32 Quite High
Inflammatory mediators 6 67.64 Quite High
cytokine 18 62.16 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 20 99.72 Very High Very High Very High
Hypertrophy 6 98.90 Very High Very High Very High
Viral Meningitis 2 98.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.16 Very High Very High Very High
Penetrating Head Injuries 10 97.00 Very High Very High Very High
Injury 110 85.40 High High
Cv General 3 Under Development 2 84.32 Quite High
INFLAMMATION 20 67.24 Quite High
Disease 8 55.24 Quite High
Stab Wounds 30 17.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Negative_regulation (diminished) of Positive_regulation (induction) of PAR1 in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
1) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.96 Pain Relevance 0.18
Our findings suggest that blocking IL-1 signaling via IL-1R1 may attenuate the activation of PAR-1 after brain injury.
Negative_regulation (blocking) of Positive_regulation (activation) of PAR-1 in brain associated with brain injury
2) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox