INT195093

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2007
Negated 2
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.66
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcan) extracellular region (Vcan) proteinaceous extracellular matrix (Vcan)
Anatomy Link Frequency
dorsal root 1
Vcan (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal column 108 99.74 Very High Very High Very High
Spinal cord 60 99.26 Very High Very High Very High
Sciatic nerve 200 81.36 Quite High
dorsal root ganglion 124 71.20 Quite High
5HT 4 65.68 Quite High
Glutamate 23 5.00 Very Low Very Low Very Low
withdrawal 20 5.00 Very Low Very Low Very Low
Peripheral nerve injury 20 5.00 Very Low Very Low Very Low
halothane 12 5.00 Very Low Very Low Very Low
unmyelinated 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 317 99.96 Very High Very High Very High
Injury 243 99.88 Very High Very High Very High
Cicatrix 22 92.68 High High
Frailty 8 89.44 High High
Gliosis 2 80.32 Quite High
Brain Injury 10 78.40 Quite High
Ganglion Cysts 128 71.20 Quite High
Viral Meningitis 1 7.84 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 7.32 Low Low
Nervous System Injury 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It would be interesting to analyse with immunohistochemistry whether these molecules are upregulated in the NG2 KO mice compared to wild-type mice in the tissues studied.
Spec (whether) Positive_regulation (upregulated) of NG2
1) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.48 Pain Relevance 0.05
NG2 is the most strongly upregulated CSPG at CNS injury sites, with a time course very closely matched to the arrested growth of axonal sprouts [13,27], and enzymatic degradation of CSPGs (in particular, removal of chondroitin sulphate glycosaminoglycans by chondroitinase ABC) promotes regenerative axonal growth in the adult CNS [29-31].
Positive_regulation (upregulated) of NG2 associated with injury
2) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.40 Pain Relevance 0.06
Specifically, we could find no evidence that regenerative growth of dorsal root axons into the spinal cord after dorsal root injury, or of ascending (sensory) axons within the spinal cord following dorsal column injury, was enhanced in the NG2 knockout mice.
Neg (no) Positive_regulation (enhanced) of NG2 in dorsal root associated with targeted disruption, injury, dorsal column and spinal cord
3) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.67 Pain Relevance 0.23
NG2 mRNA and protein levels are induced after many types of CNS injury [72].
Positive_regulation (induced) of NG2 associated with injury
4) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.87 Pain Relevance 0
Whether or not NG2 has an insignificant role in preventing axonal regeneration in the CNS – as our findings suggest – or is a contributory factor in this process, NG2 is upregulated in vigorously regenerating peripheral.
Neg (not) Positive_regulation (upregulated) of NG2
5) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.23 Pain Relevance 0.10

General Comments

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