INT195094

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.49
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
molar 1
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 23 100.00 Very High Very High Very High
imagery 6 99.64 Very High Very High Very High
Pain 5 84.84 Quite High
ischemia 6 83.68 Quite High
diabetic neuropathy 5 80.60 Quite High
Inflammation 281 68.60 Quite High
cytokine 64 66.04 Quite High
endometriosis 5 52.16 Quite High
Arthritis 10 34.48 Quite Low
rheumatoid arthritis 5 24.96 Low Low
Disease Link Frequency Relevance Heat
Stress 65 99.68 Very High Very High Very High
Apoptosis 70 99.28 Very High Very High Very High
Hyperplasia 6 93.04 High High
Death 33 88.48 High High
Syndrome 5 85.80 High High
Disease 39 84.96 Quite High
Pain 5 84.84 Quite High
Infarction 5 84.12 Quite High
Neurodegenerative Disease 16 83.92 Quite High
Diabetes Mellitus 60 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although two RAGE ligands (S100B and S100A12) also bind Zn++ very well, the effect on them is to increase their affinity for Ca++ [106,107].
S100B Binding (bind) of
1) Confidence 0.35 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0
While the interaction of RAGE with S100B can produce anti-apoptotic signals, micro-molar concentrations of S100B will produce oxyradicals, inducing apoptosis.
S100B Binding (interaction) of in molar associated with apoptosis
2) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.97 Pain Relevance 0.22
Upon binding to RAGE and activating intracellular ROS formation, S100B activates the PI 3-kinase/AKT pathway and subsequently the NF?
S100B Binding (binding) of
3) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.75 Pain Relevance 0.03
S100B binds to both the tetramerization domain and the negative regulatory domain of p53 [104].
S100B Binding (binds) of
4) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.91 Pain Relevance 0.07
S100B binds both the variable (V) and constant (C1) regions of RAGE, and oligomers of S100B bind RAGE more strongly [42,48].
S100B Binding (bind) of
5) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.87 Pain Relevance 0.04
For Immunoblotting for glutamine synthetase (GS), glutamate aspartate transporter (GLAST), glutamate transporter-1 (GLT-1), S-100B and protease-activated receptor (PAR-1), 10 ?
S-100B Binding (For) of associated with glutamate
6) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0 Pain Relevance 0.15

General Comments

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