INT195095

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.37
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
microglia 4
brain 2
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 97.88 Very High Very High Very High
Glutamate 46 96.44 Very High Very High Very High
Neuritis 1 94.76 High High
Nerve growth factor 8 74.64 Quite High
endometriosis 3 71.88 Quite High
Inflammation 187 50.00 Quite Low
cINOD 3 48.40 Quite Low
Inflammatory mediators 6 24.88 Low Low
Central nervous system 13 18.88 Low Low
psoriasis 3 17.48 Low Low
Disease Link Frequency Relevance Heat
Injury 139 99.98 Very High Very High Very High
Stab Wounds 30 99.84 Very High Very High Very High
Brain Injury 52 98.44 Very High Very High Very High
Disease 49 98.40 Very High Very High Very High
Syndrome 6 98.28 Very High Very High Very High
Cv Unclassified Under Development 5 97.88 Very High Very High Very High
Infarction 3 97.52 Very High Very High Very High
Alzheimer's Dementia 14 97.04 Very High Very High Very High
Neuritis 1 94.76 High High
Toxocariasis 45 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated levels of S100B have been found in patients following brain trauma, ischemia/infarction, Alzheimer's disease, and Down's syndrome [42].
Positive_regulation (Elevated) of Gene_expression (levels) of S100B in brain associated with syndrome, ischemia, disease, infarction and brain injury
1) Confidence 0.36 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.93 Pain Relevance 0.08
Similarly, it was suggested that elevated S100B levels are involved in the development of Down's syndrome and AD [61]; its expression was also correlated with the density of dystrophic neuritis with overexpressed A?
Positive_regulation (elevated) of Gene_expression (levels) of S100B associated with syndrome, disease and neuritis
2) Confidence 0.34 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.76 Pain Relevance 0.09
expression in microglia by S100B requires the concurrent activation of NF-?
Positive_regulation (requires) of Gene_expression (expression) of S100B in microglia
3) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0
expression in microglia by S100B requires the concurrent activation of NF-?
Positive_regulation (by) of Gene_expression (expression) of S100B in microglia
4) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0
Thus, a neocortical stab wound injury induces the expression of GLT-1, GLAST, the GS, and S-100B, but our data indicate that this induction is independent of IL-1R1.
Positive_regulation (induces) of Gene_expression (expression) of S-100B associated with injury and stab wounds
5) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.15
Our results show that in both WT and receptor-null mice, stab wound injury increased GLAST, GLT-1, GS and S-100B protein expression at 3 day post injury by 8, 6, 4 and 12 fold, respectively (Fig. 7).
Positive_regulation (increased) of Gene_expression (expression) of S-100B protein associated with injury and stab wounds
6) Confidence 0.08 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.49 Pain Relevance 0.28

General Comments

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